EMEND 125 mg hard capsulesEMEND 80 mg hard capsules

ATC Code
Medikamio Hero Image

About this drug

Admission country
Manufacturer Merck Sharp & Dohme Ltd.
Narcotic drug No
Psychotropic No
Anatomical group Alimentäres system und stoffwechsel
Therapeutic group Antiemetika und mittel gegen übelkeit
Pharmacological group Antiemetika und mittel gegen übelkeit
Chemical group Andere antiemetika
Substance Aprepitant, fosaprepitant


All to know


Merck Sharp & Dohme Ltd.

What is it?

Emend is a medicine containing the active substance aprepitant. It is available as capsules (white and yellow: 40 mg; white: 80 mg; white and pink: 125 mg).

What is it used for?

Emend is an anti-emetic (a medicine that prevents nausea [feeling sick] and vomiting). Emend 80 mg and 125 mg capsules are used with other medicines to prevent nausea and vomiting caused by chemotherapy (medicines used to treat cancer) in adults. Emend works with chemotherapy containing cisplatin (a strong trigger of nausea and vomiting) and with chemotherapy that is a moderate trigger of nausea and vomiting (such as cyclophosphamide, doxorubicin or epirubicin). Emend makes chemotherapy more tolerable for the patient.
Emend 40 mg capsules are used to prevent postoperative nausea and vomiting (PONV) in adults. This is nausea and vomiting that a patient can experience after surgery.
The medicine can only be obtained with a prescription.


How is it used?

In chemotherapy, the usual dose of Emend is one 125 mg capsule by mouth one hour before the start of chemotherapy. After chemotherapy, one 80 mg capsule is taken each day for the next two days. It must be given with other medicines that also prevent nausea and vomiting, including a corticosteroid (such as dexamethasone) and a ?5HT 3 antagonist? (such as ondansetron).
In PONV, the usual dose is one 40 mg capsule given within the three hours before the patient is anaesthetised (?put to sleep?).
Emend capsules should be swallowed whole, with or without food.

How does it work?

Emend is a neurokinin 1 (NK1) receptor antagonist. It stops a chemical in the body (substance P) from binding to the NK1 receptors. When substance P attaches to these receptors, it causes nausea and vomiting. By blocking the receptors, Emend can prevent nausea and vomiting, which often happens after chemotherapy or as a complication of surgery.

How has it been studied?

In chemotherapy, three main studies have been carried out. The first two studies involved a total of 1,094 adults receiving chemotherapy including cisplatin, and the third involved 866 patients with breast cancer who were receiving cyclophosphamide, with or without doxorubicin or epirubicin. All three studies compared the effectiveness of Emend, taken in combination with dexamethasone and ondansetron, with that of the standard combination of dexamethasone and ondansetron. The main measure of effectiveness was the number of patients who had nausea and vomiting in the five days after receiving chemotherapy.
In PONV, two studies were carried out in a total of 1,727 patients, most of whom were women undergoing gynaecological operations. Two doses of Emend (40 and 125 mg) were compared with ondansetron given as an injection. The studies measured how many patients had a ?complete response?, which was defined as no vomiting and no need for any other medication to control nausea and vomiting in the 24 hours after the operation.

What benefits has it shown during the studies?

In the chemotherapy studies, adding Emend to the standard combination was more effective than the standard combination alone. Looking at the results of the two cisplatin studies taken together, 68% of the patients taking Emend had no nausea or vomiting over five days (352 out of 520), compared with 48% of the patients who did not take it (250 out of 523). The effectiveness of Emend was also seen during a further five cycles of chemotherapy. In the study of chemotherapy that is a moderate trigger of nausea and vomiting, 51% of the patients taking Emend had no nausea or vomiting (220 out of 433), compared with 43% of the patients who did not take it (180 out of 424).
In PONV, Emend was as effective as ondansetron. Looking at the results of both studies together, 55% of the patients taking Emend at a dose of 40 mg were ?complete responders? (298 out of 541), compared with 49% of the patients who received ondansetron (258 out of 526).

What is the risk associated?

The most common side effect of Emend at all doses (seen in between 1 and 10 patients in 100) is increased liver enzymes. At 80 mg and 125 mg, the other side effects seen in between 1 and 10 patients in 100 are headache, dizziness, hiccups, constipation, diarrhoea, dyspepsia (indigestion), eructation (burping), anorexia (loss of appetite), and asthenia (weakness) or fatigue (tiredness). For the full list of all side effects reported with Emend, see the Package Leaflet.
Emend should not be used in people who may be hypersensitive (allergic) to aprepitant or any of the other ingredients. Emend 80 mg and 125 mg must not be taken with the following medicines:

  • pimozide (used to treat mental illness);
  • terfenadine, astemizole (commonly used to treat allergy symptoms - these medicines may be available without a prescription);
  • cisapride (used to relieve certain stomach problems). Emend should be used with caution when taking with some other medicines. Oral contraceptives may become less effective in patients taking Emend. For more information, see the Summary of Product Characteristics (also part of the EPAR).

Why has it been approved?

The Committee for Medicinal Products for Human Use (CHMP) decided that Emend?s benefits are greater than its risks for the prevention of PONV in adults, and of acute and delayed nausea and vomiting associated with highly emetogenic cisplatin-based cancer chemotherapy and moderately emetogenic cancer chemotherapy in adults. The Committee recommended that Emend be given marketing authorisation.



Your personal medicine assistent


Search our database for drugs, sorted from A-Z with their effects and ingredients.


All substances with their common uses, chemical components and medical products which contain them.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.

This website is certified by Health On the Net Foundation. Click to verify.