Advertisement

Author: Bayer Schering Pharma AG


Long information

What is it?

Pritor is a medicine that contains the active substance telmisartan. It is available as white tablets (round: 20 mg; oblong: 40 and 80 mg).

Advertisement

Table of Contents
What is it used for?
How is it used?
How does it work?
How has it been studied?
What benefits has it shown during the studies?
What is the risk associated?
Why has it been approved?

What is it used for?

Pritor is used in adults who have essential hypertension (high blood pressure). ?Essential? means that the hypertension has no obvious cause.
The medicine can only be obtained with a prescription.

How is it used?

Pritor is taken by mouth, with or without food. The recommended dose is 40 mg once a day, but some patients may benefit from using a 20-mg dose. If the target blood pressure is not reached, the dose can be increased to 80 mg, or another medicine for hypertension can be added, such as hydrochlorothiazide.

Advertisement

How does it work?

The active substance in Pritor, telmisartan, is an ?angiotensin II receptor antagonist?, which means that it blocks the action of a hormone in the body called angiotensin II. Angiotensin II is a powerful vasoconstrictor (a substance that narrows blood vessels). By blocking the receptors to which angiotensin II normally attaches, telmisartan stops the hormone having an effect, allowing the blood pressure to drop, reducing the risks associated with high blood pressure, such as having a stroke.

How has it been studied?

Pritor has been studied in 1,647 patients who were treated with telmisartan either alone or in combination with hydrochlorothiazide. Pritor was compared with placebo (a dummy treatment) and with other medicines for hypertension (atenolol, lisinopril, enalapril and amlodipine). The main measure of effectiveness was the reduction in diastolic blood pressure (the blood pressure measured between two heartbeats).

What benefits has it shown during the studies?

Pritor was more effective than placebo at reducing diastolic blood pressure and had similar effects to the other medicines for hypertension.

What is the risk associated?

Side effects with Pritor are not common. However, the following side effects are seen in between 1 and 10 patients in 1,000: hyperkalaemia (high blood potassium levels), syncope (fainting), insomnia (difficulty sleeping), vertigo (a spinning sensation), hypotension (low blood pressure), dyspnoea (difficulty breathing), abdominal (tummy) pain, diarrhoea, dry mouth, dyspepsia (heartburn), flatulence (gas), hyperhidrosis (excessive sweating), pruritus (itching), myalgia (muscle pain), renal impairment (kidney problems) including renal failure (kidney failure), and chest pain. For the full list of all side effects reported with Pritor, see the Package Leaflet.
Pritor should not be used in people who may be hypersensitive (allergic) to telmisartan or any of the other ingredients. It must not be used in women who are more than three months pregnant. Its use during the first three months of pregnancy is not recommended. Pritor must not be used in people who have severe liver problems or bile problems.

Why has it been approved?

The Committee for Medicinal Products for Human Use (CHMP) decided that Pritor?s benefits are greater than its risks for the treatment of essential hypertension in adults. The Committee recommended that Pritor be given marketing authorisation.

Cookies help us deliver our services. By using our services, you agree to our use of cookies. OK