For Parkinson?s disease, the starting dose is either one 0.088-mg immediate-release tablet three times a day or one 0.26-mg prolonged-release tablet once a day. The dose should be increased every five to seven days until symptoms are controlled without causing side effects that cannot be tolerated. The maximum daily dose is three 1.1-mg immediate-release tablets or one 3.15-mg prolonged-release tablet. Patients can be switched from the immediate- to the prolonged-release tablets overnight, but the dose might need to be adjusted depending on the patient?s response. Sifrol must be given less often in patients who have problems with their kidneys. If treatment is stopped for any reason, the dose should be decreased gradually.
For restless legs syndrome, Sifrol immediate-release tablets should be taken once a day, two to three hours before going to bed. The recommended starting dose is 0.088mg, but, if needed, this can be increased every four to seven days to reduce symptoms further, to a maximum of 0.54mg. The patient?s response and the need for further treatment should be evaluated after three months. The prolonged-release tablets are not suitable for restless legs syndrome.
Sifrol tablets should be swallowed with water. The prolonged-release tablets must not be chewed, divided or crushed, and should be taken around the same time every day.For more information, see the package leaflet.