Ferrous fumarate

Ferrous fumarate
ATC Code B03AA02, B03AD02
Formula C4H2FeO4
Molar Mass (g·mol−1) 169.901
Physical State solid
Density (g·cm−3) 2.435
Melting Point (°C) 280
CAS Number 141-01-5
PUB Number 6433164
Drugbank ID DB14491
Solubility leicht löslich in Wasser

Grundlagen

Iron(II) fumarate is the iron(II) salt of fumaric acid. It is available in the form of a reddish-orange powder and is used medicinally as a dietary supplement for iron deficiency. It is primarily taken orally.

Pharmakologie

Pharmacodynamics

Iron is necessary for the production of hemoglobin. Iron deficiency may result in decreased production of hemoglobin and microcytic hypochromic anemia.

Pharmacokinetics

Absorption depends on salt form, amount administered, and dosage formPersons with normal iron stores absorb 10% to 35% of an iron dose. Individuals with iron deficiency may absorb up to 95% of an iron dose.

Drug Interactions

Concomitant use of ferrous fumarate and antacids may reduce iron absorption and is therefore not recommended.

Toxizität

Side effects

Side effects are not expected at normal dosage. Some individuals may experience gastrointestinal discomfort after taking it on an empty stomach.

In acute iron overdose, symptoms first include vomiting and diarrhea. Other possible symptoms include hypotension, tachycardia, and CNS depression. At particularly high doses, shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure, and pulmonary edema may occur.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.