Basics
Iron(II) fumarate is the iron(II) salt of fumaric acid. It is available in the form of a reddish-orange powder and is used medicinally as a dietary supplement for iron deficiency. It is primarily taken orally.
| ATC Code | B03AA02, B03AD02 |
| Formula | C4H2FeO4 |
| Molar Mass (g·mol−1) | 169.901 |
| Physical State | solid |
| Density (g·cm−3) | 2.435 |
| Melting Point (°C) | 280 |
| CAS Number | 141-01-5 |
| PUB Number | 6433164 |
| Drugbank ID | DB14491 |
| Solubility | leicht löslich in Wasser |
Pharmacology
Pharmacodynamics
Iron is necessary for the production of hemoglobin. Iron deficiency may result in decreased production of hemoglobin and microcytic hypochromic anemia.
Pharmacokinetics
Absorption depends on salt form, amount administered, and dosage formPersons with normal iron stores absorb 10% to 35% of an iron dose. Individuals with iron deficiency may absorb up to 95% of an iron dose.
Drug Interactions
Concomitant use of ferrous fumarate and antacids may reduce iron absorption and is therefore not recommended.
Toxicity
Side effects
Side effects are not expected at normal dosage. Some individuals may experience gastrointestinal discomfort after taking it on an empty stomach.
In acute iron overdose, symptoms first include vomiting and diarrhea. Other possible symptoms include hypotension, tachycardia, and CNS depression. At particularly high doses, shock, metabolic acidosis, coma, hepatic necrosis and jaundice, hypoglycemia, renal failure, and pulmonary edema may occur.
Sources
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