Fever as an indicator:
One of the oldest indicators of illness in mammals, fever is one of the most common reasons for doctor visits worldwide. Fever is often noticeable as a reaction to inflammation, infection and trauma. In addition to a rise in body temperature, fever often manifests with other illness behaviors. This is exactly why it is important to know which type of medication to use (e.g.: intravenous, rectal or oral). Because if the child is experiencing respiratory distress or vomiting, for example, rectal or intravenous administration would be an alternative.
All procedures in the multicenter, randomized, double-blind, comparative phase 3 clinical trial recently published in the journal BMC Pediatrics were conducted in accordance with institutional and/or national research committee ethical standards. In this study, patients aged 6 months to 14 years with axillary (in the axilla) body temperature greater than 38°C were assigned to the study group or control group.
Method and Procedure of the Study:
The study group was first given intravenous propacetamol followed by oral placebo medication. Patients in the control group were infused intravenously with 100ml of 0.9% sodium chloride solution without propacetamol. Then oral dexibuprofen was administered. Body temperature of all patients was measured after 0.5, 1, 1.5, 2, 3, 4 and 6 hours from oral placebo or dexibuprofen. No other antipyretics or antibiotics were administered within 6 hours of placebo or dexibuprofen administration unless deemed necessary by the treating pediatrician.
A total of 263 patients (125 in the study group) from Catholic University of Korea Hospitals were enrolled. Body temperatures of patients in the study group were significantly lower (37.73°C versus 38.36°C and 37.25°C versus 37.40°C at 0.5 and 2 hours, respectively) until two hours after administration.