Alprostadil

Alprostadil
ATC Code C01EA01, C04AG01, G04BE01
Formula C20H34O5
Molar Mass (g·mol−1) 354.5
Physical State solid
Melting Point (°C) 115-116
PKS Value 4.87
CAS Number 745-65-3
PUB Number 5280723
Drugbank ID DB00770
Solubility soluble in water

Basics

Alprostadil, also known as prostaglandin E1 (PGE1), is a naturally occurring prostaglandin in the body that is also used as a drug. In infants with congenital heart defects, it is administered by slow injection into a vein to open the ductus arteriosus until surgery can be performed. By injection into the penis or insertion into the urethra, it is used to treat erectile dysfunction.

Prostaglandin E1 was first isolated in 1957 and approved for medical use in 1981. It is on the World Health Organization's list of essential medicines.

Pharmacology

Pharmacodynamics

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernous arteries and corpus cavernosum smooth muscle result in rapid arteriolar inflow and dilation of the corpus cavernosum, leading to erection.

In infants, the vasodilatory effects of alprostadil increase pulmonary and systemic blood flow. In congenital heart disease, the effects of alprostadil lead to increased oxygenation of tissues, especially lower body organs such as the kidneys. This can critically prolong the infant's survival time until surgery is possible.

Pharmacokinetics

The absolute bioavailability of alprostadil is not precisely known. It is bound in plasma primarily to albumin (81%). Alprostadil must be infused continuously because it is metabolized very rapidly. Up to 80% of circulating alprostadil may be metabolized in one pass through the lungs, mainly by beta and omega oxidation. Metabolites are excreted primarily by the kidneys, and elimination is essentially complete within 24 hours of administration. The elimination half-life is 5 to 10 minutes (after a single dose), in healthy adults and neonates.

Toxicity

Side effects

Common side effects of alprostadil may include:

  • mild pain in the penis, urethra, or testicles
  • redness of the penis
  • warmth or burning in the urethra

A doctor should be informed immediately if you experience any of the following symptoms:

  • a feeling of dizziness, as if you might faint
  • bleeding after the injection
  • a painful erection that lasts 4 hours or longer
  • new or worsening pain in your penis
  • severe redness, swelling, tenderness, nodules under the skin
  • unusual shape or curvature of the erect penis

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

Your personal medicine assistent

afgis-Qualitätslogo mit Ablauf Jahr/Monat: Mit einem Klick auf das Logo öffnet sich ein neues Bildschirmfenster mit Informationen über Medikamio GmbH & Co KG und sein/ihr Internet-Angebot: medikamio.com/ This website is certified by Health On the Net Foundation. Click to verify.
Drugs

Search our database for drugs, sorted from A-Z with their effects and ingredients.

Substances

All substances with their common uses, chemical components and medical products which contain them.

Diseases

Causes, symptoms and treatment for the most common diseases and injuries.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.