Bromazepam is an active ingredient from the benzodiazepine group, which is used to treat severe anxiety or panic attacks or insomnia due to its antianxiety and sedative properties. It is also used to relieve alcohol and opiate withdrawal symptoms.

Because of its rapid absorption and onset of action, bromazepam has a greater potential for abuse compared to other benzodiazepines, according to many psychiatric experts.

It is classified as a psychotropic substance and was approved in Germany under the trade name Lexotanil® in 1977, but was withdrawn from the market in 2016. Lexotanil® is still available in Switzerland and Austria.



The drug binds to the GABA-A receptor, causing a conformational change and potentiating the inhibitory GABA-Aergic effects. As a result, the depressant, antianxiety, anticonvulsant, and muscle relaxant effects are induced.


After oral ingestion, bioavailability is 84%. The maximum plasma level is reached after 1-4 hours. The drug circulates 70% protein-bound and has a half-life of 10-20 hours. Bromazepam is broken down in the liver via oxidative pathways and excretion occurs in the urine.


Bromazepam should not be used in case of:

  • Hypersensitivity
  • dependence on CNS depressant substances including alcohol
  • Sleep apnea
  • myasthenia gravis
  • Severe hepatic insufficiency
  • severe respiratory insufficiency
  • Pregnancy and lactation

Drug interactions

When used concomitantly with centrally sedating drugs, alcohol, and muscle relaxants, the depressant, respiratory, and hemodynamic (blood flow mechanics) effects may be mutually potentiated.


Side effects

Side effects commonly encountered at the start of therapy include fatigue, dizziness, lightheadedness, lowered blood pressure, impaired concentration, impaired reaction times, and headache.
Das Risiko einer psychischen und körperlichen Abhängigkeitsentwicklung besteht bereits nach wenigen Wochen mit täglicher Einnahme und bei einem raschen Absetzen können Entzugserscheinungen auftreten.

Toxicological data

High doses over a prolonged period of time may result in articulation difficulties and unsteadiness of movement and gait.

Chemical & physical properties

ATC Code N05BA08
Formula C14H10BrN3O
Molar Mass (g·mol−1) 316,15
Physical State solid
Melting Point (°C) 237-239
CAS Number 1812-30-2
PUB Number 2441
Drugbank ID DB01558

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All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


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