Chondroitin sulfate

Chondroitin sulfate
ATC Code G04BX17, M01AX25
Formula C13H21NO15S
Physical State solid
CAS Number 24967-93-9
PUB Number 24766
Drugbank ID DB09301
Solubility moderate in water / poor in ethanol

Basics

Chondroitin sulfate is a naturally occurring molecule in the body. It belongs to the group of glucosaminoglycans. These are formed in the chondroblasts and are an important component of cartilage tissue. Chondroitin sulfate is used for the long-term treatment of arthritis. After some time, there is relief of pain and increased mobility of the joints.

Pharmacology

Pharmacodynamics

Chondrotitin is a natural component of cartilage tissue. Its structure provides a certain stability against compression and is essential for the cartilage mass of the joints.

Pharmacokinetics

Chondroitinsuflate enters the bloodstream via the gastrointestinal tract and is 90% metabolized into minor metabolites. Oral bioavailability is approximately 20%. It takes up to 6 months for maximum effect to be achieved. Plasma protein binding is very low, at only 0.23%. Chondroitin sulfate is not broken down by the liver. The exact mechanism of how this drug is metabolized has not been elucidated. The plasma half-life is approximately 15 hours. Chondroitin sulfate is excreted through the kidneys.

Toxicity

Chondroitin is an extremely safe drug that is neither carcinogenic nor teratogenic. There are no known significant side effects.

Editorial principles

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Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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