| ATC Code | D01AE14, G01AX12 |
| CAS number | 29342-05-0 |
| PUB number | 2749 |
| Drugbank ID | DB01188 |
| Empirical formula | C12H17NO2 |
| Molar mass (g·mol−1) | 207,27 |
| Physical state | solid |
| Density (g·cm−3) | 1,2±0,1 |
| Melting point (°C) | 144 |
| Boiling point (°C) | 1440 |
Ciclopirox is a drug from the antifungal group. Chemically, the drug is a derivative of pyridone. Ciclopirox is a drug with a broad spectrum of activity. It is therefore effective against a wide range of pathogenic fungi. It is applied locally in the form of ointments or suppositories. It is also used as a salt in the form of ciclopiroxolamine. In addition, ciclopirox is used as an active component in medicinal shampoos.
Ciclopirox has the property to bind metal cations (e.g.: Fe3+ or Al3+) in chelate complexes. This inhibits the activity of certain enzymes (cytochromes), which disrupts the energy supply of the fungus and causes it to die. In addition, the drug decreases the stability of the fungi's plasma membranes, making it highly likely that they will collapse.
Ciclopirox is applied topically (superficially) only. Approximately 5% of the applied amount is absorbed through the skin. Plasma protein binding is approximately 95%. Ciclopirox is rendered ineffective and broken down in the liver by a process called glucuronidation. Finally, it is excreted in the urine. The plasma half-life is 1.7 hours on average.
No interactions with other substances are known.
Side effects after the application of ciclopirox are very rare. However, in some cases, skin reactions may occur at the site of application (redness, itching, burning).
LD50 (rat, oral) : >10 ml/kg
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
Browse our extensive database of medications from A-Z, including effects, side effects, and dosage.
All active ingredients with their effects, applications, and side effects, as well as the medications they are contained in.
Symptoms, causes, and treatments for common diseases and injuries.
The presented content does not replace the original package insert of the medication, especially regarding the dosage and effects of individual products. We cannot assume liability for the accuracy of the data, as the data has been partially converted automatically. Always consult a doctor for diagnoses and other health-related questions.
© medikamio