Ciclopirox is a drug from the antifungal group. Chemically, the drug is a derivative of pyridone. Ciclopirox is a drug with a broad spectrum of activity. It is therefore effective against a wide range of pathogenic fungi. It is applied locally in the form of ointments or suppositories. It is also used as a salt in the form of ciclopiroxolamine. In addition, ciclopirox is used as an active component in medicinal shampoos.



Ciclopirox has the property to bind metal cations (e.g.: Fe3+ or Al3+) in chelate complexes. This inhibits the activity of certain enzymes (cytochromes), which disrupts the energy supply of the fungus and causes it to die. In addition, the drug decreases the stability of the fungi's plasma membranes, making it highly likely that they will collapse.


Ciclopirox is applied topically (superficially) only. Approximately 5% of the applied amount is absorbed through the skin. Plasma protein binding is approximately 95%. Ciclopirox is rendered ineffective and broken down in the liver by a process called glucuronidation. Finally, it is excreted in the urine. The plasma half-life is 1.7 hours on average.

Drug Interactions

No interactions with other substances are known.


Side effects

Side effects after the application of ciclopirox are very rare. However, in some cases, skin reactions may occur at the site of application (redness, itching, burning).

Toxicological data

LD50 (rat, oral) : >10 ml/kg

Chemical & physical properties

ATC Code D01AE14, G01AX12
Formula C12H17NO2
Molar Mass (g·mol−1) 207,27
Physical State solid
Density (g·cm−3) 1,2±0,1
Melting Point (°C) 144
Boiling Point (°C) 1440
CAS Number 29342-05-0
PUB Number 2749
Drugbank ID DB01188

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All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


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