Cinnarizine

Cinnarizine
ATC Code N06DX12, N07CA02
Formula C26H28N2
Molar Mass (g·mol−1) 368.524
Physical State solid
CAS Number 298-57-7
PUB Number 1547484
Drugbank ID DB00568
Solubility insoluble in water

Basics

Cinnarizine is an antihistamine and calcium channel blocker from the diphenylmethylpiperazine group. It is prescribed for nausea and vomiting due to motion sickness or other causes such as chemotherapy, dizziness, or Ménière's disease. Cinnarizine is taken by mouth.

Pharmacology

Pharmacodynamics

Cinnarizine is an antihistamine and a calcium channel blocker. Histamines mediate a number of activities including contraction of airway and gastrointestinal smooth muscle, vasodilation, cardiac stimulation, secretion of gastric acid, promotion of interleukin release, and chemotaxis of eosinophils and mast cells. Cinnarizine also blocks muscarinic acetylcholine receptors. Cinnarizine also inhibits calcium channels through its action resulting in a relaxing effect on vascular smooth muscle.

Pharmacokinetics

Cinnarizine is most commonly taken orally in tablet form. After ingestion, the substance is absorbed quite rapidly and reaches maximum plasma concentration within 1-3 hours after administration. Cinnarizine is CNS-responsive due to its high lipophilicity, which is why it can have a sedative effect on patients. Cinnarizine is metabolized in the liver, after which one-third is excreted in the urine and two-thirds in the stool. The elimination half-life varies between 3.4-60 hours depending on the age of the patient.

Toxicity

Side effects

Possible side effects are

  • drowsiness
  • Sweating
  • Dry mouth
  • headache
  • Skin problems
  • Lethargy
  • Gastrointestinal irritation
  • Hypersensitivity reactions
  • Movement problems/muscle stiffness
  • Tremors

Because cinnarizine can cause drowsiness and blurred vision, it is important not to operate heavy machinery while using it if side effects become apparent.

Sources

  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

Your personal medicine assistent

afgis-Qualitätslogo mit Ablauf Jahr/Monat: Mit einem Klick auf das Logo öffnet sich ein neues Bildschirmfenster mit Informationen über Medikamio GmbH & Co KG und sein/ihr Internet-Angebot: medikamio.com/ This website is certified by Health On the Net Foundation. Click to verify.
Drugs

Search our database for drugs, sorted from A-Z with their effects and ingredients.

Substances

All substances with their common uses, chemical components and medical products which contain them.

Diseases

Causes, symptoms and treatment for the most common diseases and injuries.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.