Clioquinol

Clioquinol
ATC Code D08AH30, D09AA10, G01AC02, P01AA02, S02AA05
Formula C9H5ClINO
Molar Mass (g·mol−1) 305,50
Physical State solid
Melting Point (°C) 178–179
CAS Number 130-26-7
PUB Number 2788
Drugbank ID DB04815
Solubility soluble in water

Basics

Clioquinol (iodochlorohydroxyquin) is an antifungal, antibiotic and antiprotozoal agent. It is neurotoxic in high doses, which is why its licence for oral treatment has been withdrawn. However, it is still used to treat skin infections caused by bacteria or fungi.

Pharmacology

Pharmacodynamics

Clioquinol is a broad-spectrum antibacterial with antifungal properties. Clioquinol has a bacteriostatic effect, but the exact mechanism of action is unknown.

Pharmacokinetics

Topical absorption is rapid and extensive, especially when the skin is covered with an occlusive dressing or when the drug is applied to extensive or eroded areas of skin.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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