Basics
Clomethiazole is an active ingredient used to treat alcohol withdrawal, sleep disorders and confusion. It has a sedative, sleep-inducing and anticonvulsant effect. Clomethiazole belongs to the group of sedatives and interacts with the GABA receptors. Clomethiazole can be addictive and should therefore only be used for a short time. Interaction with the CYP450 enzymes can also lead to numerous side effects and interactions. Clomethiazole was used for many years up to the year 2000 as the most important drug to combat severe alcohol withdrawal symptoms. Clomethiazole has since been replaced by drugs with fewer side effects, such as diazepam, and is now only used very rarely.