Dequalinium

Dequalinium
ATC Code D08AH01, G01AC05, R02AA02
Formula C30H40N4+2
Molar Mass (g·mol−1) 456.678
Physical State solid
Melting Point (°C) 326
CAS Number 6707-58-0
PUB Number 2993
Drugbank ID DB04209
Solubility moderate in water / poor in ethanol

Basics

Dequalinium is a substance from the group of cationic surfactants. It is used as an antiseptic and disinfectant. It is almost always used in the form of the chloride salt dequalinium chloride. It is either applied superficially to the skin or used in the form of vaginal tablets. It is not used systemically.

Pharmacology

Pharmacodynamics

Cationic surfactants increase the cell permeability of bacteria and fungal cells. This also disrupts the enzymes of the pathogens and inactivates them. The biocidal effect occurs after approx. 30 minutes.

Pharmacokinetics

Dequalinium is absorbed only in extremely small amounts. This amount can be neglected. Pharmacokinetic parameters therefore do not play a role.

Toxicity

Side effects

Skin reactions and reactions of the mucous membranes are possible. (vaginal discharge, itching, redness, burning).

Toxicological data

LD50: 300mg/kg (oral, mouse)

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.