| ATC Code | D08AH01, G01AC05, R02AA02 |
| CAS number | 6707-58-0 |
| PUB number | 2993 |
| Drugbank ID | DB04209 |
| Empirical formula | C30H40N4+2 |
| Molar mass (g·mol−1) | 456.678 |
| Physical state | solid |
| Melting point (°C) | 326 |
Dequalinium is a substance from the group of cationic surfactants. It is used as an antiseptic and disinfectant. It is almost always used in the form of the chloride salt dequalinium chloride. It is either applied superficially to the skin or used in the form of vaginal tablets. It is not used systemically.
Cationic surfactants increase the cell permeability of bacteria and fungal cells. This also disrupts the enzymes of the pathogens and inactivates them. The biocidal effect occurs after approx. 30 minutes.
Dequalinium is absorbed only in extremely small amounts. This amount can be neglected. Pharmacokinetic parameters therefore do not play a role.
Skin reactions and reactions of the mucous membranes are possible. (vaginal discharge, itching, redness, burning).
LD50: 300mg/kg (oral, mouse)
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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