Dexpanthenol is an active ingredient of the vitamin B group that is believed to have wound-healing and moisturizing properties. It is a common ingredient in many medicines, cosmetics and medical products and is widely used for the prevention and treatment of skin and mucous membrane diseases and to support wound healing (or, for example, to heal newly stung tattoos).
Zudem wird Dexpanthenol auch zur Vorbeugung eines Vitaminmangels bei Patienten verwendet, die eine vollständige parentale Ernährung erhalten.



Dexpanthenol is an alcohol derivative of pantothenic acid (a B vitamin), which is an essential component of a normally functioning epithelium (the top cell layer of skin tissue). Enzymatically, it is cleaved to pantothenic acid, which is a component of coenzyme A. This in turn acts as a cofactor in many enzymatic reactions in which acetyl groups are transferred. These processes are important for the formation and regeneration of the skin and mucosa by causing increased fibroblast proliferation and accelerated re-epithelialization (i.e., new formation of skin tissue) during wound healing.

In addition, coenzyme A is involved in the synthesis of acetylcholine. Acetylcholine is the transmitter in the parasympathetic (involuntary) nervous system and as such maintains normal intestinal functions. Dexpanthenol may enhance the action of acetylcholine and acts on the gastrointestinal tract by increasing lower intestinal motility.


Unlike pantothenic acid, dexpanthenol is better absorbed and transported across membranes. The rate of penetration and absorption is reduced when dexpanthenol is administered as an oil/water formula, which is why the drug is usually presented on an ointment base.
Etwa 70 % einer oralen Dosis Pantothensäure werden unverändert im Urin und etwa 30 % im Stuhl ausgeschieden.


There are no known drug-drug interactions when applied to the skin.

For theoretical reasons, manufacturers of medications containing dexpanthenol recommend that it not be taken with or within 12 hours of taking neostigmine or other parasympathomimetics (substances that mimic the actions of the involuntary nervous system).
Obwohl die klinische Bedeutung nicht nachgewiesen wurde, können die pupillenverengenden Wirkungen von Anticholinesterase-Augenpräparaten (z. B. Echothiophat-Iodid, Isoflurophat) Berichten zufolge durch Pantothensäure verstärkt werden.


Side effects

Undesirable side effects, such as allergic reactions, occur rarely.

Toxicological data

LD50 (mouse, intraperitoneal): 9 g/kg
LD50 (Maus, intravenös): 7 g/kg
LD50 (Maus, oral): 15 g/kg
LD50 (Kaninchen, oral): 4 g/kg

Chemical & physical properties

ATC Code A03FA13, A11HA30, D03AX03, G02CD07, R01AX26, S01XA12
Formula C9H19NO4
Molar Mass (g·mol−1) 205,25
Physical State liquid
Density (g·cm−3) 1,2
Melting Point (°C) <25
Boiling Point (°C) 118-120
CAS Number 81-13-0
PUB Number 131204
Drugbank ID DB09357

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


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