Dienogest is an oral progestogen (hormone) which is used in combination with the synthetically produced hormone ethinylestradiol for contraception or as a monopreparation for the symptomatic treatment of endometriosis.

The hormone was synthesized and patented in 1977 by the pharmaceutical company Jenapharm.



Although Dienogest only weakly activates the progesterone receptor, it shows a very strong progestagenic effect in the endometrium, which becomes diluted after prolonged use of the hormone. In addition to relieving endometriosis symptoms, this also contributes to making it more difficult for sperm to implant.

Other contraceptive effects from Dienogest are caused by inhibiting ovulation and blocking the cervix from sperm.

In addition, Dienogest also has antiandrogenic effects, meaning it suppresses male sex hormones and relieves symptoms of acne by regulating sebum production.


After oral administration, dienogest is rapidly absorbed with a bioavailability of 90%. The maximum concentration in plasma is reached after 1.5 hours and the hormone circulates with 90% bound to albumin.
Dienogest wird vollständig durch das Enzym CYP3A4 verstoffwechselt und wird hauptsächlich mit dem Urin ausgeschieden. Die Halbwertszeit beträgt ca. 9-10 Stunden.


Side effects

Common adverse reactions include weight gain, acne, headache, breast and abdominal pain, menstrual irregularities, mood swings, and gastrointestinal disorders.

Toxicological data

LD50 (mouse, oral): 4 mg/kg

Chemical & physical properties

ATC Code G03DB08
Formula C20H25NO2
Molar Mass (g·mol−1) 311,425
Physical State solid
Melting Point (°C) 210-218
CAS Number 65928-58-7
PUB Number 68861
Drugbank ID DB09123

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


Your personal medicine assistent

afgis-Qualitätslogo mit Ablauf Jahr/Monat: Mit einem Klick auf das Logo öffnet sich ein neues Bildschirmfenster mit Informationen über medikamio GmbH & Co KG und sein/ihr Internet-Angebot: medikamio.com/ This website is certified by Health On the Net Foundation. Click to verify.

Search our database for drugs, sorted from A-Z with their effects and ingredients.


All substances with their common uses, chemical components and medical products which contain them.


Causes, symptoms and treatment for the most common diseases and injuries.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.