| ATC Code | C02DB01 |
| CAS number | 484-23-1 |
| PUB number | 10230 |
| Drugbank ID | DB12945 |
| Empirical formula | C8H10N6 |
| Molar mass (g·mol−1) | 190.210 |
| Physical state | solid |
| Melting point (°C) | 180 |
| PKS value | 4,06; 8,06 |
Dihydralazine is a prescription medication with antihypertensive properties. It belongs to the chemical class of hydrazinophthalazines. It is a derivative of the drug hydralazine. It is indicated for the treatment of arterial hypertension when first-line therapeutic agents are not effective.
It is generally administered orally and is available in tablet form.
Pharmacodynamics
The mechanism of action is not clear at the molecular level. Dihydralazine relaxes the muscles of the blood vessels. This decreases peripheral resistance and lowers blood pressure.
Pharmacokinetics
The bioavailability of dihydralazine is about 30-50%. The substance is subject to a high first-pass effect in the liver. Metabolism occurs hepatically by acetylation of the drug. The plasma half-life is four to five hours. The active substance is predominantly excreted renally.
Side effects
Contraindications
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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