Dihydralazine is a prescription medication with antihypertensive properties. It belongs to the chemical class of hydrazinophthalazines. It is a derivative of the drug hydralazine. It is indicated for the treatment of arterial hypertension when first-line therapeutic agents are not effective.
It is generally administered orally and is available in tablet form.
Effect
Pharmacodynamics
The mechanism of action is not clear at the molecular level. Dihydralazine relaxes the muscles of the blood vessels. This decreases peripheral resistance and lowers blood pressure.
Pharmacokinetics
The bioavailability of dihydralazine is about 30-50%. The substance is subject to a high first-pass effect in the liver. Metabolism occurs hepatically by acetylation of the drug. The plasma half-life is four to five hours. The active substance is predominantly excreted renally.
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Markus Falkenstätter, BSc Author
Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.
Mag. pharm. Stefanie Lehenauer Lector
Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.
The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.
