Dihydralazine

Dihydralazine
ATC Code C02DB01
Formula C8H10N6
Molar Mass (g·mol−1) 190.210
Physical State solid
Melting Point (°C) 180
PKS Value 4,06; 8,06
CAS Number 484-23-1
PUB Number 10230
Drugbank ID DB12945

Basics

Dihydralazine is a prescription medication with antihypertensive properties. It belongs to the chemical class of hydrazinophthalazines. It is a derivative of the drug hydralazine. It is indicated for the treatment of arterial hypertension when first-line therapeutic agents are not effective.

It is generally administered orally and is available in tablet form.

Pharmacology

Pharmacodynamics

The mechanism of action is not clear at the molecular level. Dihydralazine relaxes the muscles of the blood vessels. This decreases peripheral resistance and lowers blood pressure.

Pharmacokinetics

The bioavailability of dihydralazine is about 30-50%. The substance is subject to a high first-pass effect in the liver. Metabolism occurs hepatically by acetylation of the drug. The plasma half-life is four to five hours. The active substance is predominantly excreted renally.

Toxicity

Side effects

  • Headache
  • Loss of appetite
  • Nausea
  • Vomiting
  • Diarrhea
  • Palpitations
  • Increased heart rate
  • Angina pectoris

Contraindications

  • Ischemic heart disease
  • coronary artery disease
  • Valve stenosis
  • Aortic aneurysms
  • Pericarditis
Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.