Dimetinden

Dimetinden

Basics

Dimetinden is an antihistamine and anticholinergic. Dimetinden is used orally and topically as an antipruritic (anti-itch) agent. It is used topically to treat skin irritations, such as insect bites. Dimetind is also given orally to treat allergies such as hay fever and allergic rhinitis.

Effect

Pharmacodynamics

Dimethindene is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, resulting in temporary relief of negative symptoms caused by histamine. Furthermore, Dimetinden can also be used as an anticholinergic in neurological disorders.

Drug

interactionsSimultaneous

use

with tricyclic antidepressants may lead to an increased risk of glaucoma in certain individuals

.

Dimetinden may also increase the effects of centrally acting agents and alcohol.

Toxicity

As with other antihistamines, overdose may result in the following symptoms:

  • CNS depression with drowsiness (especially in adults),
  • CNS stimulation and antimuscarinic effects (especially in children) including the following symptoms: agitation, ataxia, hallucinations, tonic or clonic convulsions, mydriasis, dry mouth, redness of the face, urinary retention, fever, and tachycardia.
  • A severe drop in blood pressure is also possible.

Toxicological data

LD50 (rat, oral): 618 mg-kg-1

Chemical & physical properties

ATC Code D04AA13, R01AC09, R06AB03
Formula C20H24N2
Molar Mass (g·mol−1) 292,42
Physical State liquid
Boiling Point (°C) 165–175
CAS Number 5636-83-9
PUB Number 21855
Drugbank ID DB08801

Sources

  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.

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