Dimetinden is an antihistamine and anticholinergic. Dimetinden is used orally and topically as an antipruritic (anti-itch) agent. It is used topically to treat skin irritations, such as insect bites. Dimetind is also given orally to treat allergies such as hay fever and allergic rhinitis.
Effect
Pharmacodynamics
Dimethindene is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, resulting in temporary relief of negative symptoms caused by histamine. Furthermore, Dimetinden can also be used as an anticholinergic in neurological disorders.
Drug
interactionsSimultaneous
use
with tricyclic antidepressants may lead to an increased risk of glaucoma in certain individuals
.
Dimetinden may also increase the effects of centrally acting agents and alcohol.
Toxicity
As with other antihistamines, overdose may result in the following symptoms:
CNS depression with drowsiness (especially in adults),
CNS stimulation and antimuscarinic effects (especially in children) including the following symptoms: agitation, ataxia, hallucinations, tonic or clonic convulsions, mydriasis, dry mouth, redness of the face, urinary retention, fever, and tachycardia.
Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
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Markus Falkenstätter, BSc Author
Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.
Mag. pharm. Stefanie Lehenauer Lector
Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.
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