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Dimetinden

ATC CodeD04AA13, R01AC09, R06AB03
CAS number5636-83-9
PUB number21855
Drugbank IDDB08801
Empirical formulaC20H24N2
Molar mass (g·mol−1)292,42
Physical stateliquid
Boiling point (°C)165–175
Basics
Pharmacology
Toxicity

Basics

Dimetinden is an antihistamine and anticholinergic. Dimetinden is used orally and topically as an antipruritic (anti-itch) agent. It is used topically to treat skin irritations, such as insect bites. Dimetind is also given orally to treat allergies such as hay fever and allergic rhinitis.

Pharmacology

Pharmacodynamics

Dimethindene is a selective histamine H1 antagonist and binds to the histamine H1 receptor. This blocks the action of endogenous histamine, resulting in temporary relief of negative symptoms caused by histamine. Furthermore, Dimetinden can also be used as an anticholinergic in neurological disorders.

Drug

interactionsSimultaneous

use

with tricyclic antidepressants may lead to an increased risk of glaucoma in certain individuals

.

Dimetinden may also increase the effects of centrally acting agents and alcohol.

Toxicity

As with other antihistamines, overdose may result in the following symptoms:

  • CNS depression with drowsiness (especially in adults),
  • CNS stimulation and antimuscarinic effects (especially in children) including the following symptoms: agitation, ataxia, hallucinations, tonic or clonic convulsions, mydriasis, dry mouth, redness of the face, urinary retention, fever, and tachycardia.
  • A severe drop in blood pressure is also possible.

Toxicological data

LD50 (rat, oral): 618 mg-kg-1

Sources

  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

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