Basics
Domperidone is an active substance from the class of antiemetics (anti-nausea drugs). It is used to treat nausea and vomiting, for example during chemotherapy. Domperidone requires a prescription and is usually administered in tablet form.
Effect
Pharmacodynamics
Domperidone is a so-called dopamine antagonist. It blocks the dopamine receptors D2 and D3. These are responsible for the development of nausea and vomiting and can no longer be activated as often in the presence of domperidone, resulting in a reduction of these symptoms.
PharmacokineticsDomperidone is absorbed into the blood via the intestine, where it is present bound to proteins by 93%. The elimination half-life is 7 hours. Degradation occurs in the liver and is catalyzed by enzymes of the CYP450 system.
Toxicity
Side effects
Side effects include an increase in prolactin levels and QT prolongation of heart rhythm, menstrual cramps, and sexual dysfunction.
| ATC Code | A03FA03 |
| Formula | C22H24ClN5O2 |
| Molar Mass (g·mol−1) | 425,91 |
| Physical State | solid |
| Melting Point (°C) | 242,5 |
| PKS Value | 7,9 |
| CAS Number | 57808-66-9 |
| PUB Number | 3151 |
| Drugbank ID | DB01184 |
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