ATC Code A03FA03
Formula C22H24ClN5O2
Molar Mass (g·mol−1) 425,91
Physical State solid
Melting Point (°C) 242,5
PKS Value 7,9
CAS Number 57808-66-9
PUB Number 3151
Drugbank ID DB01184
Solubility practically insoluble in water, sparingly soluble in ethanol and methanol, soluble in DMF


Domperidone is an active substance from the class of antiemetics (anti-nausea drugs). It is used to treat nausea and vomiting, for example during chemotherapy. Domperidone requires a prescription and is usually administered in tablet form.



Domperidone is a so-called dopamine antagonist. It blocks the dopamine receptors D2 and D3. These are responsible for the development of nausea and vomiting and can no longer be activated as often in the presence of domperidone, resulting in a reduction of these symptoms.


Domperidone is absorbed into the blood via the intestine, where it is present bound to proteins by 93%. The elimination half-life is 7 hours. Degradation occurs in the liver and is catalyzed by enzymes of the CYP450 system.


Side effects

Side effects include an increase in prolactin levels and QT prolongation of heart rhythm, menstrual cramps, and sexual dysfunction.

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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