Drospirenone is a synthetic progesterone derivative used in some hormonal contraceptives and hormone replacement therapies. When used as a contraceptive, it is administered either in combination with an estrogen or as a monopreparation in the form of the so-called mini-pill. Other uses include the treatment of moderate acne vulgaris and the symptomatic treatment of premenstrual dysphoric disorder. It is taken perorally in the form of a tablet.
It was originally developed by Schering AG in the 1970s and has been on the market since the 2000s.