ATC Code G03DB01
Formula C21H28O2
Molar Mass (g·mol−1) 312.446
Physical State solid
Melting Point (°C) 144
Boiling Point (°C) 463
CAS Number 152-62-5
PUB Number 9051
Drugbank ID DB00378
Solubility insoluble in water


Dydrogesterone is a drug from the group of progestins. Dydrogesterone is a synthetic derivative of the natural hormone progesterone, which acts in the same way. Dydrogesterone is approved for the treatment of menstrual disorders and for hormonal replacement therapy.

This medicine requires a prescription and is usually taken in the form of film-coated tablets.



act by binding to progesterone receptors on the cell membrane or inside the cell (intracellular). The intracellular receptors bind to the DNA of the cell after contact with a progestin and thus regulate protein expression. Dydrogesterone binds mainly to receptors in the uterus. This promotes healthy growth and shedding of the uterine lining. Dydrogesterone, unlike other progestins, is not contraceptive.


Dydrogesterone has an oral bioavailability of 28%. It is broken down in the cells of the liver and has a plasma half-life of approximately 5-7 hours.


There are no known cases of severe overdoses.

Toxicological data

LD50: 4,640mg/kg (rat, oral)

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

Your personal medicine assistent

afgis-Qualitätslogo mit Ablauf Jahr/Monat: Mit einem Klick auf das Logo öffnet sich ein neues Bildschirmfenster mit Informationen über Medikamio GmbH & Co KG und sein/ihr Internet-Angebot: medikamio.com/ This website is certified by Health On the Net Foundation. Click to verify.

Search our database for drugs, sorted from A-Z with their effects and ingredients.


All substances with their common uses, chemical components and medical products which contain them.


Causes, symptoms and treatment for the most common diseases and injuries.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.