Dydrogesterone

Dydrogesterone is a drug from the group of progestins. Dydrogesterone is a synthetic derivative of the natural hormone progesterone, which acts in the same way. Dydrogesterone is approved for the treatment of menstrual disorders and for hormonal replacement therapy.

This medicine requires a prescription and is usually taken in the form of film-coated tablets.

PharmacodynamicsGestagens

act by binding to progesterone receptors on the cell membrane or inside the cell (intracellular). The intracellular receptors bind to the DNA of the cell after contact with a progestin and thus regulate protein expression. Dydrogesterone binds mainly to receptors in the uterus. This promotes healthy growth and shedding of the uterine lining. Dydrogesterone, unlike other progestins, is not contraceptive.

Pharmacokinetics

Dydrogesterone has an oral bioavailability of 28%. It is broken down in the cells of the liver and has a plasma half-life of approximately 5-7 hours.

There are no known cases of severe overdoses.

Toxicological data

LD50: 4,640mg/kg (rat, oral)