ATC Code M01AH05
Formula C18H15ClN2O2S
Molar Mass (g·mol−1) 358,84
Physical State solid
CAS Number 202409-33-4
PUB Number 123619
Drugbank ID DB01628
Solubility practically insoluble in water


Etoricoxib is a new COX-2 selective inhibitor and belongs to the group of so-called NSAIDs (Non Steroidal Anti Inflammatory Drugs). Indications are: Treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain, and gout. Etoricoxib is available by prescription only.



Etoricoxib is a new COX-2 selective inhibitor. The enzyme cyclooxygenase is significantly involved in inflammatory processes and in the development of pain. Etoricoxib selectively inhibits the isoenzyme COX-2.


Bioavailability is 100% after oral administration. Plasma protein binding is approximately 92 %. Elimination is hepatic, mainly via the enzyme CYP3A4. The half-life is about 22 hours.


Side effects

Possible adverse effects:

  • Increase or decrease in blood pressure
  • back pain
  • edema (ankles, legs)
  • Numbness
  • GIT: stomach pain, flatulence
  • Decrease in glomerular filtration rate, oliguria
  • Blood clotting disorders, anemia
  • Sore throat
  • Itching

In addition, there is an increased risk of thromboembolic events with the use of coxiben due to selective inhibition of COX-2. Therefore, use is contraindicated in cardiovascular risk patients.


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