Etoricoxib

Etoricoxib

Basics

Etoricoxib is a new COX-2 selective inhibitor and belongs to the group of so-called NSAIDs (Non Steroidal Anti Inflammatory Drugs). Indications are: Treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, chronic low back pain, acute pain, and gout. Etoricoxib is available by prescription only.

Effect

Pharmacodynamics

Etoricoxib is a new COX-2 selective inhibitor. The enzyme cyclooxygenase is significantly involved in inflammatory processes and in the development of pain. Etoricoxib selectively inhibits the isoenzyme COX-2.

Pharmacokinetics

Bioavailability is 100% after oral administration. Plasma protein binding is approximately 92 %. Elimination is hepatic, mainly via the enzyme CYP3A4. The half-life is about 22 hours.

Toxicity

Side effects

Possible adverse effects:

  • Increase or decrease in blood pressure
  • back pain
  • edema (ankles, legs)
  • Numbness
  • GIT: stomach pain, flatulence
  • Decrease in glomerular filtration rate, oliguria
  • Blood clotting disorders, anemia
  • Sore throat
  • Itching

In addition, there is an increased risk of thromboembolic events with the use of coxiben due to selective inhibition of COX-2. Therefore, use is contraindicated in cardiovascular risk patients.

Chemical & physical properties

ATC Code M01AH05
Formula C18H15ClN2O2S
Molar Mass (g·mol−1) 358,84
Physical State solid
CAS Number 202409-33-4
PUB Number 123619
Drugbank ID DB01628

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.

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