Flucloxacillin is a penicillin antibiotic with a narrow spectrum of activity that is specifically effective against Gram-positive organisms. It is indicated for the treatment of skin infections, external ear infections, leg ulcer infections, diabetic foot infections, and bone infections. It may be used with other medications to treat pneumonia and endocarditis. Flucloxacillin cannot be used for methicillin-resistant Staphylococcus aureus (MRSA) infections. It is administered orally or parenterally.
The substance was developed because of increasing bacterial resistance to established antibiotics. Flucloxacillin was patented in 1961 and was first marketed in Europe in the 1970s.