ATC Code D07AB03, D07XB01
Formula C22H28F2O5
Molar Mass (g·mol−1) 410.5
Physical State solid
Melting Point (°C) 219
CAS Number 2135-17-3
PUB Number 16490
Drugbank ID DB00663
Solubility practically insoluble in water


Flumethasone is a moderately potent difluorinated corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties. Normally not the pure substance but the pivalate salt is used. Thus its anti-inflammatory effect is concentrated on the site of application. This local effect leads to a prompt decrease of inflammation, exudation and itching.



Flumethasone is a glucocorticoid receptor agonist. The flumethasone/receptor complex binds to the nucleus and initiates a variety of genetic mechanisms. The anti-inflammatory effects of corticosteroids are thought to be related to lipocortins, phospholipase A2 inhibitory proteins that control the biosynthesis of prostaglandins and leukotrienes by inhibiting arachidonic acid. The immune system is also suppressed by a variety of mechanisms corticosteroids.


Because flumethasone is used almost exclusively on the skin, very few data are known on the pharmacokinetic properties of this drug.


Side effects

  • local skin reactions such as burning, itching, skin dryness and rash
  • skin damage such as atrophy and striae
  • systemic side effects with large area application


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Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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