Flumethasone is a moderately potent difluorinated corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties. Normally not the pure substance but the pivalate salt is used. Thus its anti-inflammatory effect is concentrated on the site of application. This local effect leads to a prompt decrease of inflammation, exudation and itching.
Effect
Pharmacodynamics
Flumethasone is a glucocorticoid receptor agonist. The flumethasone/receptor complex binds to the nucleus and initiates a variety of genetic mechanisms. The anti-inflammatory effects of corticosteroids are thought to be related to lipocortins, phospholipase A2 inhibitory proteins that control the biosynthesis of prostaglandins and leukotrienes by inhibiting arachidonic acid. The immune system is also suppressed by a variety of mechanisms corticosteroids.
Pharmacokinetics
Because flumethasone is used almost exclusively on the skin, very few data are known on the pharmacokinetic properties of this drug.
Toxicity
Side effects
local skin reactions such as burning, itching, skin dryness and rash
Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
Editorial principles
All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc Author
Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.
Mag. pharm. Stefanie Lehenauer Lector
Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.
The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.
