| ATC Code | D07AB03, D07XB01 |
| CAS number | 2135-17-3 |
| PUB number | 16490 |
| Drugbank ID | DB00663 |
| Empirical formula | C22H28F2O5 |
| Molar mass (g·mol−1) | 410.5 |
| Physical state | solid |
| Melting point (°C) | 219 |
Flumethasone is a moderately potent difluorinated corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive properties. Normally not the pure substance but the pivalate salt is used. Thus its anti-inflammatory effect is concentrated on the site of application. This local effect leads to a prompt decrease of inflammation, exudation and itching.
Flumethasone is a glucocorticoid receptor agonist. The flumethasone/receptor complex binds to the nucleus and initiates a variety of genetic mechanisms. The anti-inflammatory effects of corticosteroids are thought to be related to lipocortins, phospholipase A2 inhibitory proteins that control the biosynthesis of prostaglandins and leukotrienes by inhibiting arachidonic acid. The immune system is also suppressed by a variety of mechanisms corticosteroids.
PharmacokineticsBecause flumethasone is used almost exclusively on the skin, very few data are known on the pharmacokinetic properties of this drug.
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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