Flupentixol is a highly potent member of the neuroleptic drug class. It is used for the treatment of schizophrenia. It is used especially in patients with poor compliance and many relapses. For this reason, it is often administered as an injection given several times a week.

Flupentixol is available only on prescription.



Flupentixol is an antianxiety and mood elevating neuroleptic. It is a high-affinity antagonist at the dopamine receptors D1 and D2. This increases the neurotransmitters serotonin and norepinephrine, which exert a positive effect on mood and thinking.


Absorption after oral administration is rather slow and poor. Flupentixol is more than 95% bound to plasma proteins. It is primarily cleared by the liver and subsequently excreted in the urine. The elimination half-life is 19-39 hours.


Toxicological data

LD50=300 mk/kg (oral, mouse)

LD50=87 mk/kg (IV, mouse)

Chemical & physical properties

ATC Code N05AF01
Formula C23H25F3N2OS
Molar Mass (g·mol−1) 434.52
Physical State solid
CAS Number 2709-56-0
PUB Number 5281881
Drugbank ID DB00875

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


Your personal medicine assistent

afgis-Qualitätslogo mit Ablauf Jahr/Monat: Mit einem Klick auf das Logo öffnet sich ein neues Bildschirmfenster mit Informationen über medikamio GmbH & Co KG und sein/ihr Internet-Angebot: medikamio.com/ This website is certified by Health On the Net Foundation. Click to verify.

Search our database for drugs, sorted from A-Z with their effects and ingredients.


All substances with their common uses, chemical components and medical products which contain them.


Causes, symptoms and treatment for the most common diseases and injuries.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.