| ATC Code | N05AF01 |
| CAS number | 2709-56-0 |
| PUB number | 5281881 |
| Drugbank ID | DB00875 |
| Empirical formula | C23H25F3N2OS |
| Molar mass (g·mol−1) | 434.52 |
| Physical state | solid |
Flupentixol is a highly potent member of the neuroleptic drug class. It is used for the treatment of schizophrenia. It is used especially in patients with poor compliance and many relapses. For this reason, it is often administered as an injection given several times a week.
Flupentixol is available only on prescription.
Flupentixol is an antianxiety and mood elevating neuroleptic. It is a high-affinity antagonist at the dopamine receptors D1 and D2. This increases the neurotransmitters serotonin and norepinephrine, which exert a positive effect on mood and thinking.
Absorption after oral administration is rather slow and poor. Flupentixol is more than 95% bound to plasma proteins. It is primarily cleared by the liver and subsequently excreted in the urine. The elimination half-life is 19-39 hours.
LD50=300 mk/kg (oral, mouse)
LD50=87 mk/kg (IV, mouse)
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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