Flupentixol

Flupentixol
ATC Code N05AF01
Formula C23H25F3N2OS
Molar Mass (g·mol−1) 434.52
Physical State solid
CAS Number 2709-56-0
PUB Number 5281881
Drugbank ID DB00875
Solubility sparingly soluble in water

Basics

Flupentixol is a highly potent member of the neuroleptic drug class. It is used for the treatment of schizophrenia. It is used especially in patients with poor compliance and many relapses. For this reason, it is often administered as an injection given several times a week.

Flupentixol is available only on prescription.

Pharmacology

Pharmacodynamics

Flupentixol is an antianxiety and mood elevating neuroleptic. It is a high-affinity antagonist at the dopamine receptors D1 and D2. This increases the neurotransmitters serotonin and norepinephrine, which exert a positive effect on mood and thinking.

Pharmacokinetics

Absorption after oral administration is rather slow and poor. Flupentixol is more than 95% bound to plasma proteins. It is primarily cleared by the liver and subsequently excreted in the urine. The elimination half-life is 19-39 hours.

Toxicity

Toxicological data

LD50=300 mk/kg (oral, mouse)

LD50=87 mk/kg (IV, mouse)

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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