Basics

Flupentixol is a highly potent member of the neuroleptic drug class. It is used for the treatment of schizophrenia. It is used especially in patients with poor compliance and many relapses. For this reason, it is often administered as an injection given several times a week.

Flupentixol is available only on prescription.

Pharmacology

Pharmacodynamics

Flupentixol is an antianxiety and mood elevating neuroleptic. It is a high-affinity antagonist at the dopamine receptors D1 and D2. This increases the neurotransmitters serotonin and norepinephrine, which exert a positive effect on mood and thinking.

Pharmacokinetics

Absorption after oral administration is rather slow and poor. Flupentixol is more than 95% bound to plasma proteins. It is primarily cleared by the liver and subsequently excreted in the urine. The elimination half-life is 19-39 hours.

Toxicity

Toxicological data

LD50=300 mk/kg (oral, mouse)

LD50=87 mk/kg (IV, mouse)

Author

Markus Falkenstätter, BSc

Pharmacy student

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Reviewer

Mag. pharm. Stefanie Brandauer

Pharmacist

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

Editorial principles

All information used for our content comes from verified sources (recognised institutions, specialists, studies by renowned universities). We place great value on the qualification of the authors and the scientific background of the information, so that our research is based on scientific evidence.