Flupredniden

Flupredniden is a synthetic glucocorticoid corticosteroid. In its pure form, it cannot be used as a drug. It is therefore administered in the form of the salt fluprednidene acetate. It is a moderately potent glucocorticoid used in the form of creams to treat skin inflammations such as atopic dermatitis and contact dermatitis.

Pharmacodynamics

The mechanism of action is similar to that of other glucocorticoids. Flupredniden can penetrate the membrane of the cell and then bind with high affinity to intracellular glucocorticoid receptors. The anti-inflammatory (anti-inflammatory) effect is achieved by interfering with the so-called arachidonic acid metabolism. Prednisolone causes fewer prostaglandins and leukotrienes to be produced at the end of this metabolism. These are significantly involved in the inflammatory process of the human body.

Side effects

Side effects include typical corticosteroid reactions such as:

• Skin atrophy
• Skin dryness
• Teleangiectasia
• Stretch marks
• Steroid acne
• Redness
• Itching

These side effects most commonly occur when large areas of skin (more than 10% of body surface area) are treated, when treatment is continued for more than two to four weeks, under occlusive therapy, or when treated in skin folds. Hypersensitivity reactions have also been described.

Contraindications 

• Infectious skin diseases caused by viruses, bacteria, or fungi (for example, tuberculosis, syphilis, acne, chickenpox, etc.).
• rosacea, dermatitis perioralis, herpes zoster
• Pregnancy and lactation