Flupredniden

Flupredniden
ATC Code D07AB07, D07XB03
Formula C22H27FO5
Molar Mass (g·mol−1) 390.451
Physical State solid
CAS Number 1255-35-2
PUB Number 11794741
Drugbank ID DB08970

Basics

Flupredniden is a synthetic glucocorticoid corticosteroid. In its pure form, it cannot be used as a drug. It is therefore administered in the form of the salt fluprednidene acetate. It is a moderately potent glucocorticoid used in the form of creams to treat skin inflammations such as atopic dermatitis and contact dermatitis.

Pharmacology

Pharmacodynamics

The mechanism of action is similar to that of other glucocorticoids. Flupredniden can penetrate the membrane of the cell and then bind with high affinity to intracellular glucocorticoid receptors. The anti-inflammatory (anti-inflammatory) effect is achieved by interfering with the so-called arachidonic acid metabolism. Prednisolone causes fewer prostaglandins and leukotrienes to be produced at the end of this metabolism. These are significantly involved in the inflammatory process of the human body.

Toxicity

Side effects

Side effects include typical corticosteroid reactions such as:

  • Skin atrophy
  • Skin dryness
  • Teleangiectasia
  • Stretch marks
  • Steroid acne
  • Redness
  • Itching

These side effects most commonly occur when large areas of skin (more than 10% of body surface area) are treated, when treatment is continued for more than two to four weeks, under occlusive therapy, or when treated in skin folds. Hypersensitivity reactions have also been described.

Contraindications 

  • Infectious skin diseases caused by viruses, bacteria, or fungi (for example, tuberculosis, syphilis, acne, chickenpox, etc.).
  • rosacea, dermatitis perioralis, herpes zoster
  • Pregnancy and lactation

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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