ATC Code N05AG01
Formula C29H31F2N3O
Molar Mass (g·mol−1) 475.584
Physical State solid
Melting Point (°C) 187.5-190
PKS Value 8.66
CAS Number 1841-19-6
PUB Number 3396
Drugbank ID DB04842
Solubility sparingly soluble in water


Fluspirilene is a long-acting antipsychotic used in chronic schizophrenia. It is formulated as a sustained-release drug and administered parenterally.



Fluspirilene does not differ significantly in its action from other antipsychotics such as fluphenazine or perphenazine. Like the other representatives of this group, fluspirilene blocks dopamine receptors and thus achieves its sedative, drive-reducing and, above all, antipsychotic effect.


Side effects

  • Fatigue
  • Sleep disorders
  • hypertension
  • Cardiac arrhythmias
  • tachycardia
  • Dry mouth
  • Nausea,
  • vomiting
  • Diarrhea

Contraindications and precautions

The drug must not be used in diseases caused by dopamine deficiency. This includes mainly Parkinson's disease.

The effect of sleeping pills and alcohol may be enhanced by concomitant use of fluspirilene.

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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