Fluspirilen

ATC CodeN05AG01
CAS number1841-19-6
PUB number3396
Drugbank IDDB04842
Empirical formulaC29H31F2N3O
Molar mass (g·mol−1)475.584
Physical statesolid
Melting point (°C)187.5-190
PKS value8.66

Basics

Fluspirilene is a long-acting antipsychotic used in chronic schizophrenia. It is formulated as a sustained-release drug and administered parenterally.

Pharmacology

Pharmacodynamics

Fluspirilene does not differ significantly in its action from other antipsychotics such as fluphenazine or perphenazine. Like the other representatives of this group, fluspirilene blocks dopamine receptors and thus achieves its sedative, drive-reducing and, above all, antipsychotic effect.

Toxicity

Side effects

  • Fatigue
  • Sleep disorders
  • hypertension
  • Cardiac arrhythmias
  • tachycardia
  • Dry mouth
  • Nausea,
  • vomiting
  • Diarrhea

Contraindications and precautions

The drug must not be used in diseases caused by dopamine deficiency. This includes mainly Parkinson's disease.

The effect of sleeping pills and alcohol may be enhanced by concomitant use of fluspirilene.

Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer



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