Fluticasone

Fluticasone

Basics

Fluticasone is a synthetic glucocorticoid. It is available in 2 forms. Fluticasone furoate and fluticasone propionate. They are used in inhalers, nasal sprays and topical preparations for various inflammatory conditions. These include fluticasone is available by prescription only.

Drugs with Fluticasone

Drug Substance(s) Authorisation holder
ALISADE 27.5 micrograms/spraynasal spray suspension Fluticasone furoate Glaxo Group Ltd.
AVAMYS 27.5 micrograms/spraynasal spray suspension Fluticasone furoate Glaxo Group Ltd.

Effect

Pharmacodynamics

Fluticasone acts because of its structural similarity to endogenous glucocorticoids. Unbound, it can penetrate the membrane of the cell and then bind with high affinity to intracellular glucocorticoid receptors.

The anti-inflammatory (anti-inflammatory) effect is achieved by interfering with the so-called arachidonic acid metabolism. Fluticasone causes fewer prostaglandins and leukotrienes to be produced at the end of this metabolism. These are significantly involved in the inflammatory process of the human body.

Fluticasone has an anti-allergic effect by preventing the release of histamine and simultaneously reducing the number and activity of certain B and T lymphocytes.

Pharmacokinetics

Plasma protein binding is approximately 99%. Metabolism occurs in the liver and is mainly catalyzed by the enzyme CYP3A4. Excretion is mainly via faeces (>90%).

Toxicity

Side effects

The most common side effect is yeast infections in the mouth (oral thrush). Furthermore, hoarseness, headache and fatigue may occur. To reduce the undesirable effects in the oral cavity, the mouth should be rinsed thoroughly with water after use.

In very rare cases, systemic and possibly serious side effects may occur. These include bone loss, edema, allergic reactions and impaired adrenocortical function.

Toxicological Data

LD50 (rat, oral): > 2000 mg-kg-1

Chemical & physical properties

ATC Code D07AC17, R01AD08, R03BA05
Formula C22H27F3O4S
Molar Mass (g·mol−1) 444,51
Physical State solid
CAS Number 90566-53-3
PUB Number 5311101
Drugbank ID DB13867

Sources

  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.

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