Basics
Melitracene is a tricyclic antidepressant (TCA), used to treat depression and anxiety.
Gramicidin
| ATC Code | R02AB30 |
| CAS number | 5118-29-6 |
| PUB number | 25382 |
| Drugbank ID | DB13384 |
| Empirical formula | C21H25N |
| Molar mass (g·mol−1) | 291,43 |
| Physical state | solid |
| Melting point (°C) | 245–248 |
Pharmacology
Pharmacodynamics
The pharmacology of melitracene has not been adequately studied and is largely unknown, but it probably acts similarly to other TCAs. These act by inhibiting serotonin reuptake. This increases the concentration of serotonin between neurons. This results in the antidepressant and anti-anxiety effects.
Toxicity
Side effects
- Dry mouth
- Accommodative disorders
- Tachycardia
- hyperhidrosis
- orthostatic complaints
Toxicological data
LD50 (rat, oral): 170 mg-kg-1
Sources
- PubChem
- Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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