Formula C28H34O15
Molar Mass (g·mol−1) 610,56
Physical State solid
Melting Point (°C) 258–262
CAS Number 520-26-3
PUB Number 10621
Drugbank ID DB04703
Solubility wenig löslich in Wasser: 20 mg·l−


Hesperidin is a naturally occurring substance that belongs to the group of flavonoids. Within this group of substances it belongs to the flavanones. Hesperidin is composed of the flavone hesperitin and the sugar rutoside. As the main flavonoid, it is mainly found in the mesocarp of citrus fruit peels. Hesperidin was first isolated from bitter orange peels by the French pharmacist Lebreton in 1828.


  • Chronic venous insufficiency
  • Edema
  • leg ulcer

Administration is exclusively oral.



Hesperidin is mainly used in combination with diosmin, which also belongs to the flavonoids, for the treatment of venous complaints such as varicose veins. The effect is mainly based on the antioxidant effects of the flavonoids. In addition, the substance causes lymphatic drainage and an increase in venous tone to a lesser extent.

Clinical studies also indicate a positive effect in the treatment of hemorrhoids, as well as high cholesterol levels.


Toxicological data

1000 mg-kg-1 (LD50, mouse, i.p.)

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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