Hesperidin is a naturally occurring substance that belongs to the group of flavonoids. Within this group of substances it belongs to the flavanones. Hesperidin is composed of the flavone hesperitin and the sugar rutoside. As the main flavonoid, it is mainly found in the mesocarp of citrus fruit peels. Hesperidin was first isolated from bitter orange peels by the French pharmacist Lebreton in 1828.


  • Chronic venous insufficiency
  • Edema
  • leg ulcer

Administration is exclusively oral.



Hesperidin is mainly used in combination with diosmin, which also belongs to the flavonoids, for the treatment of venous complaints such as varicose veins. The effect is mainly based on the antioxidant effects of the flavonoids. In addition, the substance causes lymphatic drainage and an increase in venous tone to a lesser extent.

Clinical studies also indicate a positive effect in the treatment of hemorrhoids, as well as high cholesterol levels.


Toxicological data

1000 mg-kg-1 (LD50, mouse, i.p.)

Chemical & physical properties

Formula C28H34O15
Molar Mass (g·mol−1) 610,56
Physical State solid
Melting Point (°C) 258–262
CAS Number 520-26-3
PUB Number 10621
Drugbank ID DB04703

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


Your personal medicine assistent

afgis-Qualitätslogo mit Ablauf Jahr/Monat: Mit einem Klick auf das Logo öffnet sich ein neues Bildschirmfenster mit Informationen über medikamio GmbH & Co KG und sein/ihr Internet-Angebot: medikamio.com/ This website is certified by Health On the Net Foundation. Click to verify.

Search our database for drugs, sorted from A-Z with their effects and ingredients.


All substances with their common uses, chemical components and medical products which contain them.


Causes, symptoms and treatment for the most common diseases and injuries.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.