Isoconazole

Isoconazole is a drug used to treat fungal infections of the skin, nails, and hair. It belongs to a class of medications called azole antifungals. These work by disrupting the cell membrane of fungi, making it harder for them to grow and multiply. Isoconazole is used in the form of creams, solutions or ointments.

Isoconazole was first patented in 1970.

Pharmacodynamics and mechanism of action

Isoconazole is a broad-spectrum antifungal agent effective against a wide range of fungi, including dermatophytes, yeasts, and molds. Isoconazole's mechanism of action is based on inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Ergosterol is an important component of the fungal cell membrane, as it affects its structure and function. Inhibition of the synthesis of ergosterol alters the structure and function of the fungal cell membrane, making it difficult for fungi to grow and multiply and ultimately leading to their death.

Pharmacokinetics

Isoconazole is usually applied topically to affected skin sites, nails or hair. It is rapidly absorbed through the skin and reaches therapeutic concentrations in affected tissues. It is metabolized by the liver and excreted mainly in the urine.

Interactions

Since the Isoconazole is used only topically, interactions with other drugs are unlikely.

Side effects

Common side effects of isoconazole include:

• Skin irritation
• Redness
• Itching at the application site.

More serious side effects, although rare, may include allergic reactions and liver damage.

Contraindications and precautions

Isoconazole should not be used by individuals with a known allergy to this or other azole antifungals. It should be used with caution in individuals with liver disease or weakened immune systems. It is not recommended for use during pregnancy or lactation.