Isoconazole

Isoconazole
ATC Code D01AC05, G01AF07
Formula C18H14Cl4N2O
Molar Mass (g·mol−1) 416.12
Physical State solid
Melting Point (°C) 179
CAS Number 27523-40-6
PUB Number 3760
Drugbank ID DB08943

Basics

Isoconazole is a drug used to treat fungal infections of the skin, nails, and hair. It belongs to a class of medications called azole antifungals. These work by disrupting the cell membrane of fungi, making it harder for them to grow and multiply. Isoconazole is used in the form of creams, solutions or ointments.

Isoconazole was first patented in 1970.

Pharmacology

Pharmacodynamics and mechanism of action

Isoconazole is a broad-spectrum antifungal agent effective against a wide range of fungi, including dermatophytes, yeasts, and molds. Isoconazole's mechanism of action is based on inhibition of the synthesis of ergosterol, an important component of the fungal cell membrane. Ergosterol is an important component of the fungal cell membrane, as it affects its structure and function. Inhibition of the synthesis of ergosterol alters the structure and function of the fungal cell membrane, making it difficult for fungi to grow and multiply and ultimately leading to their death.

Pharmacokinetics

Isoconazole is usually applied topically to affected skin sites, nails or hair. It is rapidly absorbed through the skin and reaches therapeutic concentrations in affected tissues. It is metabolized by the liver and excreted mainly in the urine.

Interactions

Since the Isoconazole is used only topically, interactions with other drugs are unlikely.

Toxicity

Side effects

Common side effects of isoconazole include:

  • Skin irritation
  • Redness
  • Itching at the application site.

More serious side effects, although rare, may include allergic reactions and liver damage.

Contraindications and precautions

Isoconazole should not be used by individuals with a known allergy to this or other azole antifungals. It should be used with caution in individuals with liver disease or weakened immune systems. It is not recommended for use during pregnancy or lactation.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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