Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain-relieving), anti-inflammatory and antipyretic (fever-reducing) properties. It is available in oral and parenteral formulations. Lornoxicam is used to treat various types of pain, especially inflammatory conditions of the joints, osteoarthritis, surgery, sciatica, and other inflammatory conditions.



Like other NSAIDS, the anti-inflammatory and analgesic effects of lornoxicam are due to its inhibitory action on prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2. This results in the reduction of inflammation, pain, fever and swelling mediated by prostaglandins.


Lornoxicam is rapidly and almost completely absorbed from the GI tract (90-100%). It is 99% bound to plasma proteins (almost exclusively to serum albumin). Lornoxicam is completely metabolized by CYP2C9, so only negligible amounts of intact lornoxicam are excreted unchanged in the urine. Approximately 2/3 of the drug is excreted by the liver and 1/3 by the kidneys in the active form. The half-life is 3-5 hours.

Drug Interactions

Drug interactions are typical with NSAIDs. Combination with vitamin K antagonists such as warfarin increases the risk of bleeding. Combination with ciclosporin may result in decreased renal function and, in rare cases, acute kidney injury. Lornoxicam may also increase the adverse effects of lithium, methotrexate and digoxin and its derivatives. The effect of diuretics, ACE inhibitors and angiotensin II receptor antagonists may be reduced, but this is only relevant in patients with special risks such as heart failure.


Side effects

Lornoxicam has side effects similar to other NSAIDs, mostly mild such as gastrointestinal discomfort (nausea and diarrhea) and headache.

Severe but rare side effects include bleeding, bronchospasm, and the extremely rare Stevens-Johnson syndrome.

Toxicological Data

LD50 (rat, oral): 3.857 mol-kg-1

Chemical & physical properties

ATC Code M01AC05
Formula C13H10ClN3O4S2
Molar Mass (g·mol−1) 371,82
Physical State solid
Melting Point (°C) 225–230
PKS Value 4,78
CAS Number 70374-39-9
PUB Number 54690031
Drugbank ID DB06725


  • PubChem
  • Drugbank
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017

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All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


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