| ATC Code | J01AA04 |
| CAS number | 992-21-2 |
| PUB number | 54707177 |
| Drugbank ID | DB00256 |
| Empirical formula | C29H38N4O10 |
| Molar mass (g·mol−1) | 602.6 |
| Physical state | solid |
| Melting point (°C) | 192.5 |
| PKS value | 2.50 |
Lymecycline is a second-generation, broad-spectrum tetracycline antibiotic used to treat acne and other susceptible bacterial infections. Some of these infections include upper respiratory tract infections, urinary tract infections, bronchitis, chlamydial infections, and rickettsial infections.
Lymecycline binds to the so-called 30S ribosomal subunit and thus prevents aminoacyl-tRNA from binding to the ribosome, which prevents the elongation of polypeptide chains (proteins). This leads to a bacteriostatic effect and thus inhibits the multiplication of pathogens.
Lymecycline is 77-88% absorbed after oral administration with a relative bioavailability of 70%. Lymecycline is excreted 25% in the urine. The half-life of lymecycline is approximately 8 hours.
Side effects of lymecycline include:
Prolonged use may cause reflux esophagitis.
LD50 (rat, oral): 3200 mg/kg
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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