ATC Code J01AA04
Formula C29H38N4O10
Molar Mass (g·mol−1) 602.6
Physical State solid
Melting Point (°C) 192.5
PKS Value 2.50
CAS Number 992-21-2
PUB Number 54707177
Drugbank ID DB00256
Solubility moderate in water / poor in ethanol


Lymecycline is a second-generation, broad-spectrum tetracycline antibiotic used to treat acne and other susceptible bacterial infections. Some of these infections include upper respiratory tract infections, urinary tract infections, bronchitis, chlamydial infections, and rickettsial infections.



Lymecycline binds to the so-called 30S ribosomal subunit and thus prevents aminoacyl-tRNA from binding to the ribosome, which prevents the elongation of polypeptide chains (proteins). This leads to a bacteriostatic effect and thus inhibits the multiplication of pathogens.


Lymecycline is 77-88% absorbed after oral administration with a relative bioavailability of 70%. Lymecycline is excreted 25% in the urine. The half-life of lymecycline is approximately 8 hours.


Side effects

Side effects of lymecycline include:

  • Skin rash
  • headache
  • diarrhea
  • nausea
  • Vomiting
  • Dermatitis
  • Liver inflammation
  • Hypersensitivity reactions
  • Visual disturbances

Prolonged use may cause reflux esophagitis.

Toxicological data

LD50 (rat, oral): 3200 mg/kg


  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017

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All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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