Mebendazole belongs to the chemical group of benzimidazoles. It is used to treat diseases caused by worms.

Mebendazole shows effect on the following organisms:

  • Tapeworms
  • Hookworms
  • Whipworms
  • Trichinae
  • Pinworms
  • Roundworms

So it is an anthelmintic. Mebendazole is available by prescription and is usually given in tablet form.



Mebendazole interferes with the cellular metabolism of worms. It binds to the protein β-tubulin. This disrupts the integrity of the worm cells and metabolic transport. It thereby prevents the absorption of glucose in the digestive tract of the worms. As a result, the parasite runs out of energy reserves after a certain time and dies. The substance has no effect on humans,


Only 5-10% of mebendazole is absorbed in the gastrointestinal tract. This percentage can be increased somewhat by fatty food. The active substance is present in the blood bound to proteins to 90-99%. It is primarily broken down in the cells of the liver by the enzymes of the CYP450 system. Only 2% of the ingested dose is metabolized and excreted in the urine. The majority is excreted unchanged in the stool. The elimination half-life is between 2 and 5 hours.

Drug Interactions

Carbamazepine, metronidazole and phenytoin should not be taken concurrently as they may increase or decrease plasma levels of Mebendazole. Therefore, drastic side effects or lack of effectiveness may occur.


Side effects

Mebendazole is usually well tolerated. Typical side effects after taking mebendazole are gastrointestinal symptoms such as abdominal pain, diarrhea and flatulence. Furthermore, dizziness, headache, nausea and vomiting may occur.

Signs of overdose include elevated liver enzyme levels, fever, hair loss, pruritus and neutropenia.

Toxicological data

(LD50): 620 mg/kg [Mouse, Oral]

Chemical & physical properties

ATC Code P02CA01
Formula C16H13N3O3
Molar Mass (g·mol−1) 295,29
Physical State solid
Melting Point (°C) 288–289
PKS Value 6.6
CAS Number 31431-39-7
PUB Number 4030
Drugbank ID DB00643


  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


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