Mebeverin

Mebeverin
ATC Code A03AA04
Formula C25H35NO5
Molar Mass (g·mol−1) 429,55
Physical State solid
Melting Point (°C) 129–131
CAS Number 3625-06-7
PUB Number 4031
Drugbank ID DB12554
Solubility sparingly soluble in water

Basics

Mebeverine is an antispasmodic drug used for the symptomatic treatment of stomach pain and cramps associated with irritable bowel syndrome and other gastrointestinal disorders. It is a derivative of papaverine, which occurs naturally in the opium poppy, and is classified in the spasmolytic group of substances. Mebeverine is administered orally in the form of sustained-release capsules. It was first approved in 1965.

Pharmacology

Pharmacodynamics

Mebeverine is a spasmolytic whose exact mechanism of action is not well known. However, it acts very selectively directly on smooth muscle in the gastrointestinal tract and may have an anesthetic effect. In addition, it appears to affect calcium channels and muscarinic receptors.

Pharmacokinetics

Mebeverine is metabolized primarily by esterases in the liver. The metabolites are excreted in the urine.

Toxicity

Side effects

Adverse effects include:

  • Hypersensitivity reactions
  • Immune system disorders
  • Skin disorders including hives and rashes
  • Edema
  • Heartburn
  • Digestive disorders
  • Fatigue
  • Diarrhea
  • Constipation
  • Loss of appetite
  • General malaise
  • Dizziness
  • Insomnia
  • Headache
  • Decreased pulse rate

In a urine drug screening test, mebeverine may cause a false positive result for amphetamines.

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.