| ATC Code | A03AA04 |
| CAS number | 3625-06-7 |
| PUB number | 4031 |
| Drugbank ID | DB12554 |
| Empirical formula | C25H35NO5 |
| Molar mass (g·mol−1) | 429,55 |
| Physical state | solid |
| Melting point (°C) | 129–131 |
Mebeverine is an antispasmodic drug used for the symptomatic treatment of stomach pain and cramps associated with irritable bowel syndrome and other gastrointestinal disorders. It is a derivative of papaverine, which occurs naturally in the opium poppy, and is classified in the spasmolytic group of substances. Mebeverine is administered orally in the form of sustained-release capsules. It was first approved in 1965.
Pharmacodynamics
Mebeverine is a spasmolytic whose exact mechanism of action is not well known. However, it acts very selectively directly on smooth muscle in the gastrointestinal tract and may have an anesthetic effect. In addition, it appears to affect calcium channels and muscarinic receptors.
Pharmacokinetics
Mebeverine is metabolized primarily by esterases in the liver. The metabolites are excreted in the urine.
Side effects
Adverse effects include:
In a urine drug screening test, mebeverine may cause a false positive result for amphetamines.
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
Browse our extensive database of medications from A-Z, including effects, side effects, and dosage.
All active ingredients with their effects, applications, and side effects, as well as the medications they are contained in.
Symptoms, causes, and treatments for common diseases and injuries.
The presented content does not replace the original package insert of the medication, especially regarding the dosage and effects of individual products. We cannot assume liability for the accuracy of the data, as the data has been partially converted automatically. Always consult a doctor for diagnoses and other health-related questions.
© medikamio