Methocarbamol is a drug used for short-term musculoskeletal pain. Methocarbamol is often used in combination with physical therapy and pain medications. It is less appropriate for lower back pain. It is also used to a limited extent in rheumatoid arthritis and cerebral palsy. It generally takes effect within half an hour. It is administered by mouth or by injection into a vein.

Methocarbamol was developed in the early 1950s to treat muscle spasticity and associated pain.



Methacarbamol is a skeletal muscle relaxant with an unknown mechanism of action. However, the mechanism of action of methacarbamol is thought to depend on its depressant effect on the central nervous system. Methacarbamol has been shown to act via blockade of spinal polysynaptic reflexes and decreases nerve transmission in spinal and supraspinal polysynaptic pathways. It also prolongs the refractory period of muscle cells. The substance has no effects on contraction of muscle fibers, motor endplates, or nerve fibers.


Time to maximum concentration is approximately 1 hour in both healthy patients and hemodialysis patients. Methocarbamol is 46-50% protein-bound in healthy patients. Methocarbamol is metabolized in the liver by demethylation and conjugated by glucuronidation or sulfation and excreted in the urine. The elimination half-life is approximately 1.14 hours.


Side effects

Methocarbamol is a centrally acting skeletal muscle relaxant that has significant adverse effects, particularly on the central nervous system.

Possible side effects include:

  • Drowsiness
  • blurred vision
  • Headache
  • Nausea
  • Skin rash

Other less common side effects include:

  • Ataxia
  • stomach upset
  • mood changes
  • difficulty urinating
  • itching
  • Fever


In combination with benzodiazepines, barbiturates, codeine, or other muscle relaxants, methocarbamol may cause it to cause potentially life-threatening respiratory depression.

Methocarbamol should not be taken during pregnancy. It is also not recommended to be taken during breastfeeding.

Chemical & physical properties

ATC Code M03BA03
Formula C11H15NO5
Molar Mass (g·mol−1) 241,24
Physical State solid
Melting Point (°C) 92
CAS Number 532-03-6
PUB Number 4107
Drugbank ID DB00423

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


Your personal medicine assistent

afgis-Qualitätslogo mit Ablauf Jahr/Monat: Mit einem Klick auf das Logo öffnet sich ein neues Bildschirmfenster mit Informationen über medikamio GmbH & Co KG und sein/ihr Internet-Angebot: This website is certified by Health On the Net Foundation. Click to verify.

Search our database for drugs, sorted from A-Z with their effects and ingredients.


All substances with their common uses, chemical components and medical products which contain them.


Causes, symptoms and treatment for the most common diseases and injuries.

The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. We cannot assume any liability for the correctness of the data, as the data was partly converted automatically. A doctor should always be consulted for diagnoses and other health questions. Further information on this topic can be found here.