Methylprednisolone aceponate

Methylprednisolone aceponate
ATC Code D07AC14
Formula C27H36O7
Molar Mass (g·mol−1) 472,578
CAS Number 86401-95-8
PUB Number 63019
Drugbank ID DB14643


Methylprednisolone aceponate is a topical glucocorticoid and has anti-inflammatory, anti-allergic and suppressive effects on the body's immune system. It is used for the topical local treatment of skin diseases such as chronic inflammatory dermatitis, allergic contact dermatitis and other inflammations of the upper skin layer.

The active ingredient is marketed under the name Advantan® as a cream or ointment.



After penetration into the skin, the active ingredient is metabolized by esterases (enzymes) to active intermediates. Like other topical glucocorticoids, methylpredisolone aceponate binds to intracellular glucocorticoid receptors inside the cell. The receptor-drug complex exerts an influence on DNA, causing the synthesis of anti-inflammatory proteins. This allows the antipruritic, immunosuppressive, and anti-inflammatory/allergic effects to develop.


The decisive factor for the absorption of topical glucocorticoids is skin age. In children under 12 months of age, it must be noted that the barrier function of the skin has not yet fully developed. In the elderly, glucocorticoid absorption may increase due to thinning of the skin as well as increased skin surface area due to wrinkling.


Methylprednisolone aceponate is contraindicated in:

  • Hypersensitivity
  • Bacterial skin diseases
  • viral diseases of the skin
  • Rosacea
  • Perioral dermatitis
  • Skin ulcers
  • Acne
  • Athrophic skin diseases
  • Postvaccinal skin reactions in the treatment area


Side effects

A burning or itching sensation at the application site is the most common adverse side effect. In addition, athrophies (thinning of the skin) may occur, as well as skin striae and visible dilatation of small blood vessels of the skin.

Toxicological data

LD50 (rat, oral): > 2 g/kg
LD50 (Ratte, subkutan): > 3 g/kg

Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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