After penetration into the skin, the active ingredient is metabolized by esterases (enzymes) to active intermediates. Like other topical glucocorticoids, methylpredisolone aceponate binds to intracellular glucocorticoid receptors inside the cell. The receptor-drug complex exerts an influence on DNA, causing the synthesis of anti-inflammatory proteins. This allows the antipruritic, immunosuppressive, and anti-inflammatory/allergic effects to develop.
The decisive factor for the absorption of topical glucocorticoids is skin age. In children under 12 months of age, it must be noted that the barrier function of the skin has not yet fully developed. In the elderly, glucocorticoid absorption may increase due to thinning of the skin as well as increased skin surface area due to wrinkling.
Methylprednisolone aceponate is contraindicated in:
- Bacterial skin diseases
- viral diseases of the skin
- Perioral dermatitis
- Skin ulcers
- Athrophic skin diseases
- Postvaccinal skin reactions in the treatment area