Mirtazapine is a tetracyclic antidepressant used to treat major depression. It is particularly commonly used when insomnia or an anxiety disorder are present in addition to depression.
Mirtazapine is used off-label for a variety of conditions, including panic disorder, generalized anxiety disorder, dysthymia, tension headaches, hot flashes, post-traumatic stress disorder, sleep disorders, substance abuse, and sexual dysfunction.
Mirtazapine was first synthesized by Organon and patented in 1989. In 1994, it was approved in the Netherlands for the treatment of major depressive disorder and was introduced in the United States in 1996.