Mometasone

Mometasone and its most common salt mometasone furoate are moderately potent members of the glucocorticoid group. Glucocorticoids are hormones produced in the adrenal cortex that have anti-inflammatory properties. Mometasone has anti-inflammatory, antipruritic and vasoconstrictive effects. The main uses of mometasone are the treatment of bronchial asthma, the treatment of various skin conditions and the treatment of allergic rhinitis.

Mometasone is available as a cream or ointment, nasal spray or as an agent for inhalation.

Pharmacodynamics

Mometasone acts because of its structural similarity to endogenous glucocorticoids. Unbound it can penetrate the membrane of the cell and then bind with high affinity to intracellular glucocorticoid receptors.

The anti-inflammatory (anti-inflammatory) effect is achieved by interfering with the so-called arachidonic acid metabolism. Mometasone causes less prostaglandins and leukotrienes to be produced at the end of this metabolism. These are significantly involved in the inflammatory process of the human body.

Mometasone has an anti-allergic effect by preventing the release of histamine and simultaneously reducing the number and activity of certain B and T lymphocytes.

Pharmacokinetics

Mometasone is degraded by enzymes of the CYP450 system in cells of the liver. It has a plasma half-life of approximately 5-8 hours and is 98-99% bound to plasma proteins.

The chances of overdose when using an inhaler or cream are low.

Signs of overdose are: Acne, muscle weakness, and weight gain.

Side effects

Possible side effects of using mometasone include local skin irritation such as irritation, redness, itching, and rashes.