ATC Code D07AC13, D07XC03, R01AD09, R03BA07
Formula C22H28Cl2O4, C27H30Cl2O6 (Furoat)
Molar Mass (g·mol−1) 427.361, 521,4 (Furoat)
Physical State solid
Melting Point (°C) 218-220
CAS Number 105102-22-5
PUB Number 441335
Drugbank ID DB00764
Solubility practically insoluble in water, sparingly soluble in ethanol 96%, soluble in dichloromethane and acetone


Mometasone and its most common salt mometasone furoate are moderately potent members of the glucocorticoid group. Glucocorticoids are hormones produced in the adrenal cortex that have anti-inflammatory properties. Mometasone has anti-inflammatory, antipruritic and vasoconstrictive effects. The main uses of mometasone are the treatment of bronchial asthma, the treatment of various skin conditions and the treatment of allergic rhinitis.

Mometasone is available as a cream or ointment, nasal spray or as an agent for inhalation.



Mometasone acts because of its structural similarity to endogenous glucocorticoids. Unbound it can penetrate the membrane of the cell and then bind with high affinity to intracellular glucocorticoid receptors.

The anti-inflammatory (anti-inflammatory) effect is achieved by interfering with the so-called arachidonic acid metabolism. Mometasone causes less prostaglandins and leukotrienes to be produced at the end of this metabolism. These are significantly involved in the inflammatory process of the human body.

Mometasone has an anti-allergic effect by preventing the release of histamine and simultaneously reducing the number and activity of certain B and T lymphocytes.


Mometasone is degraded by enzymes of the CYP450 system in cells of the liver. It has a plasma half-life of approximately 5-8 hours and is 98-99% bound to plasma proteins.


The chances of overdose when using an inhaler or cream are low.

Signs of overdose are: Acne, muscle weakness, and weight gain.

Side effects

Possible side effects of using mometasone include local skin irritation such as irritation, redness, itching, and rashes.

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Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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