| CAS number | 2444-46-4 |
| PUB number | 2998 |
| Drugbank ID | DB11324 |
| Empirical formula | C17H27NO3 |
| Molar mass (g·mol−1) | 293,401 |
| Density (g·cm−3) | 1,0 |
| Melting point (°C) | 57 |
| Boiling point (°C) | 492,7 |
| PKS value | 9,77 |
| Solubility | 0.007716 mg/mL |
Nonylvanillamide, nonivamide or pseudocapsaicin is an active ingredient used to treat pain and inflammation. It belongs to the group of capsaicinoids and is mainly applied as an ointment, gel or cream to affected areas of skin. Typical areas of application are sports injuries, tension, muscle and joint pain. Nonylvanillamide is also an ingredient in pepper sprays, which are used by the police, among others. Nonivamide is mainly found in plants and spices and is extracted from pepper.
Pseudocapsaicin works by being applied to the skin as an ointment, cream or gel and binding to the TRPV1 pain receptors. This binding leads to an increase in local temperature and subsequently to a desensitization of the pain receptors and thus to pain relief. This desensitization is caused by the reduction in the number of substance P, which is responsible for the peripheral sensations.
The half-life of nonylvanillamide, i.e. the time the body needs to excrete half of the active substance, is around 7 minutes.
Always take nonylvanillamide exactly as described in the package leaflet or as advised by your doctor.
Adults:
The ointment should be applied as thinly and as little as possible on first application in order to wait for skin reactions. If no symptoms occur during the first application, the ointment can be applied 2-3 times a day to the affected area.
However, the maximum daily dose should NOT exceed 3 applications.
The following side effects may occur:
Frequent:
Occasional:
Frequency unknown:
No known interactions.
Nonylvanillamide must NOT be taken in the following cases:
Nonylvanillamide should NOT be used under 18 years of age due to lack of data on safety and efficacy.
Nonylvanillamide should NOT be used during pregnancy and lactation due to a lack of data on safety and efficacy.
Thomas Hofko
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