| ATC Code | R05DA07 |
| CAS number | 128-62-1 |
| PUB number | 275196 |
| Drugbank ID | DB06174 |
| Empirical formula | C22H23NO7 |
| Molar mass (g·mol−1) | 413,4205 |
| Physical state | solid |
| Density (g·cm−3) | 1,395 |
| Melting point (°C) | 176 |
| PKS value | 6,24 |
Noscapine is an active ingredient derived from the opium poppy. The natural component of opium has no analgesic or depressant properties and therefore has no addictive potential. It mainly has a cough-suppressing effect and is used for irritable coughs.
Since the effect is somewhat weaker than that of codeine, the drug can also be used in infants from six months of age (under a doctor's prescription).
The antitussive effects are due to an attack of the cough center in the brainstem. Activation of sigma opioid receptors induces cell division inhibitory effects. Because of this mechanism of action, noscapine is also a potential agent for tumor treatment.
The pharmacokinetic properties are comparable to those of codeine. The drug is absorbed through the gastrointestinal tract, with only about 5-10% of the administered dose being converted to morphine in the liver. The remaining components are broken down to ineffective intermediates and excreted renally. After about three hours, the plasma concentration of the compound drops to half of the initial level.
Concurrent use of noscapine with sleeping pills, sedatives, antidepressants, antipsychotics, opioids, and alcohol is not recommended.
Occasional side effects may include headache, dizziness, skin and hypersensitivity reactions, and nausea.
LD50 (mouse, oral): 2784 mg/kg
LD50 (Hund, intravenös): 73 mg/kg
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
Browse our extensive database of medications from A-Z, including effects, side effects, and dosage.
All active ingredients with their effects, applications, and side effects, as well as the medications they are contained in.
Symptoms, causes, and treatments for common diseases and injuries.
The presented content does not replace the original package insert of the medication, especially regarding the dosage and effects of individual products. We cannot assume liability for the accuracy of the data, as the data has been partially converted automatically. Always consult a doctor for diagnoses and other health-related questions.
© medikamio