Ofloxacin is an antibiotic used to treat bacterial infections in many parts of the body, including the respiratory tract, kidney, skin, soft tissue, and urinary tract.
Es wird weitgehend äußerlich als Augen- und Ohrentropfen eingesetzt.



Ofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Its mode of action depends on blocking bacterial DNA replication (duplication) by binding itself to an enzyme called DNA gyrase. This enzyme allows the untwisting of the DNA double helix, which is necessary to replicate it into two.
Das Medikament hat eine 100-mal höhere Affinität für die bakterielle DNA-Gyrase als für die von Säugetieren.


The bioavailability in the tablet formulation is approximately 98%.
32% des Medikaments werden an Plasmaproteine gebunden.
Das Arzneimittel wird hauptsächlich renal ausgeschieden, wobei zwischen 65% und 80% einer verabreichten oralen Ofloxacin-Dosis innerhalb von 48 Stunden nach der Einnahme unverändert über den Urin ausgeschieden werden. Etwa 4-8 % einer Ofloxacin-Dosis werden mit den Fäzes ausgeschieden, das Arzneimittel unterliegt nur einer minimalen biliären Ausscheidung.


Ofloxacin may interact with other drugs. Co-administration of some fluoroquinolone anti-infectives (e.g., ciprofloxacin, norfloxacin, ofloxacin) in patients taking theophylline may result in higher and prolonged serum theophylline concentrations, potentially increasing the risk of theophylline-related adverse reactions. The magnitude of this interaction varies considerably among commercially available fluoroquinolones; the effect is less pronounced with norfloxacin or ofloxacin than with ciprofloxacin.

Concomitant use of a fluoroquinolone with fenbufen (a nonsteroidal anti-inflammatory agent) may increase the risk of CNS stimulation (e.g., seizures).

Oral multivitamin and mineral supplements containing, for example, iron or zinc may decrease the oral absorption of ofloxacin, resulting in decreased serum concentrations of quinolone. Therefore, these multivitamins and/or mineral supplements should not be taken concomitantly with or within 2 hours of an ofloxacin dose.

In addition, the drug should not be taken with caffeinated beverages or foods, if possible.


Side effects

Adverse reactions include local reactions such as stinging, pain, hypersensitivity reactions, and rarely deposits.
Möglich, aber selten, sind systemische Nebenwirkungen wie allergische Reaktionen sowie Geruchs- und Geschmacksstörungen.

Bei 1 bis 2 % der mit Ofloxacin behandelten Patienten treten leichte Erhöhungen des ALT- und des alkalischen Phosphatasespiegel auf. Diese meist asymptomatischen Begleiterscheinungen klingen von selbst bei Fortsetzung der Therapie ab.

In rare cases, ofloxacin has been associated with acute liver injury.

Toxicological data

LD50 (rat, oral): 5450 mg/kg.

Chemical & physical properties

ATC Code J01MA01, S01AE01, S02AA16
Formula C18H20FN3O4
Molar Mass (g·mol−1) 361,4
Physical State solid
Melting Point (°C) 254
PKS Value 5,35
CAS Number 82419-36-1
PUB Number 4583
Drugbank ID DB01165

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


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