Common side effects are euphoria, constipation, nausea, vomiting, loss of appetite, drowsiness, dizziness, itching, dry mouth, and sweating.
Severe side effects may include addiction, dependence, hallucinations, respiratory depression (a decrease in breathing), bradycardia, and low blood pressure. Those who are allergic to codeine may also be allergic to oxycodone.
The use of oxycodone in early pregnancy appears to be relatively safe.
The risk of experiencing severe withdrawal symptoms is high if a patient has become physically dependent and oxycodone is abruptly discontinued. If oxycodone has been taken regularly for a long period of time, it should be discontinued gradually rather than abruptly. People who take oxycodone regularly as a recreational drug or at higher than prescribed doses are at even higher risk for severe withdrawal symptoms. Symptoms of oxycodone withdrawal, as with other opioids, may include anxiety, panic attacks, nausea, insomnia, muscle pain, muscle weakness, fever, and other flu-like symptoms.
LD50 (rat, oral): 320 mg-kg-1