Oxytetracycline

Oxytetracycline is a broad-spectrum antibiotic that is effective against a wide range of bacteria. However, some strains of bacteria have developed resistance to this antibiotic, which has reduced its effectiveness in treating some types of infections.
Oxytetracyclin wird zur Behandlung von Infektionen verwendet, die durch Chlamydien verursacht werden (z. B. Psittakose,Trachom und Urethritis) und Infektionen, die durch Mycoplasma-Organismen verursacht werden (z. B. Lungenentzündung).
Oxytetracyclin wird auch zur Behandlung von Akne eingesetzt und zur Behandlung von Schüben der chronischen Bronchitis eingesetzt. Außerdem kann es auch zur Behandlung von anderen, selteneren Infektionen eingesetzt werden, wie z. B. Rocky-Mountain-Fleckfieber.

Pharmacodynamics

Oxytetracycline inhibits cell growth by inhibiting protein translation. It binds to the 30S ribosomal subunit and prevents amino-acyl-tRNA binding to the A site of the ribosome. Oxytetracycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Binding to the bacterial ribosome prevents protein synthesis and thus pathogen replication.

Pharmacokinetics

Oxytetracycline is rapidly absorbed after oral administration.

Side effects

Side effects are mainly gastrointestinal and phototoxic reactions, which are typical for the group of tetracycline antibiotics. It can also damage calcium-rich organs, such as teeth and bones, but this is extremely rare. Candidiasis is also possible after treatment with broad-spectrum antibiotics.

Toxicological data

LD50 (rat, oral): 4800 mg-kg-1