Phenazone

Phenazone
ATC Code N02BB01, S02DA03
Formula C11H12N2O
Molar Mass (g·mol−1) 188,23
Physical State solid
Density (g·cm−3) 1,19
Melting Point (°C) 111–114
Boiling Point (°C) 319
PKS Value 1.4
CAS Number 60-80-0
PUB Number 2206
Drugbank ID DB01435
Solubility soluble in water

Basics

Phenazone is an analgesic, a non-steroidal anti-inflammatory drug (NSAID) and an antipyretic. It is taken by mouth or in the form of ear drops. Phenazone, also called antipyrine, is now rarely used to treat pain and fever. However, it is often used in testing the effects of other drugs or diseases on drug-degrading enzymes in the liver.

Pharmacology

Pharmacodynamics

The anti-inflammatory, analgesic, and antipyretic effects of phenazone are due to inhibition of the enzymes cyclooxygenase-1 and -2 (COX-1/COX-2), enzymes involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins, which mediate pain, fever and inflammation.

Toxicity

Side effects

Possible adverse effects include:

  • allergy to pyrazolones
  • Nausea
  • Agranulocytosis
  • Hepatotoxicity

Toxicological data

LD50 (rat, oral): 1705 mg-kg-1

Sources

  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017 
  • Drugbank
  • PubChem

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All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.

Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

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