| ATC Code | N02BB01, S02DA03 |
| CAS number | 60-80-0 |
| PUB number | 2206 |
| Drugbank ID | DB01435 |
| Empirical formula | C11H12N2O |
| Molar mass (g·mol−1) | 188,23 |
| Physical state | solid |
| Density (g·cm−3) | 1,19 |
| Melting point (°C) | 111–114 |
| Boiling point (°C) | 319 |
| PKS value | 1.4 |
Phenazone is an analgesic, a non-steroidal anti-inflammatory drug (NSAID) and an antipyretic. It is taken by mouth or in the form of ear drops. Phenazone, also called antipyrine, is now rarely used to treat pain and fever. However, it is often used in testing the effects of other drugs or diseases on drug-degrading enzymes in the liver.
Pharmacodynamics
The anti-inflammatory, analgesic, and antipyretic effects of phenazone are due to inhibition of the enzymes cyclooxygenase-1 and -2 (COX-1/COX-2), enzymes involved in prostaglandin synthesis via the arachidonic acid pathway. This results in decreased levels of prostaglandins, which mediate pain, fever and inflammation.
Possible adverse effects include:
LD50 (rat, oral): 1705 mg-kg-1
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
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