Basics
Pipamperone is a typical antipsychotic of the butyrophenone family and is used to treat schizophrenia and as a sleep aid for depression.
Pipamperon
| ATC Code | N05AD05 |
| CAS number | 1893-33-0 |
| PUB number | 4830 |
| Drugbank ID | DB09286 |
| Empirical formula | C21H30FN3O2 |
| Molar mass (g·mol−1) | 375,48 |
| Physical state | solid |
| Melting point (°C) | 124,5–126 |
Pharmacology
Pharmacodynamics
Pipamperone binds primarily to 5-HT2A receptors, with nearly equal affinity to D4 receptors and moderate affinity to 5-HT2C, D2-3, and alpha-adrenoceptors. Pipamperone has a 15-fold higher affinity for D4 than for D2 receptors. Binding to the above receptors results in the antipsychotic and antidepressant effects.
Pharmacokinetics
Pipamperone is taken orally and metabolized in the liver. Excretion is mainly by the kidneys. The half-life is about 16-27 hours.
Toxicity
Side effects
- Dyskinesia
- Loss of appetite
- Nausea
- Vomiting
- Hyperprolactinemia
- Menstrual irregularities
- Increased pulse
- QT prolongation (ECG)
- Depression
- Fatigue
- Drowsiness
- Insomnia
- Headache
Toxicological data
LD50 (rat, oral): 160 mg-kg-1
Sources
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
Your personal medication assistant
Drugs
Browse our extensive database of medications from A-Z, including effects, side effects, and dosage.
Substances
All active ingredients with their effects, applications, and side effects, as well as the medications they are contained in.
Diseases
Symptoms, causes, and treatments for common diseases and injuries.
The presented content does not replace the original package insert of the medication, especially regarding the dosage and effects of individual products. We cannot assume liability for the accuracy of the data, as the data has been partially converted automatically. Always consult a doctor for diagnoses and other health-related questions.
© medikamio