Piritramid

Piritramid
ATC Code N02AC03
Formula C27H34N4O
Molar Mass (g·mol−1) 430,59
Physical State solid
Melting Point (°C) 225–227
CAS Number 302-41-0
PUB Number 9331
Drugbank ID DB12492
Solubility low in water

Basics

Piritramide is a synthetic opioid analgesic marketed in certain European countries, including: Austria, Belgium, Czech Republic, Germany and the Netherlands. It is available in free form, is approximately 0.75 times more potent than morphine and is administered parenterally (by injection) for the treatment of severe pain.

Pharmacology

Pharmacodynamics

Piritramide is a synthetic opioid and a µ-receptor agonist. Thus, the analgesic effect is due to binding to µ-receptors in the CNS.

Pharmacokinetics

After intravenous administration, the onset of analgesia is only 1-2 minutes, possibly related to its large lipophilicity. The volume of distribution is 0.7-1 L/kg after a single dose, 4.7-6 L/kg after steady-state concentrations are reached, and up to 11.1 L/kg after prolonged administration.

Contraindication

  • severe obstructive pulmonary disease (COPD)
  • concomitant use with MAO inhibitors
  • Respiratory depression
  • Coma
  • hypersensitivity

Toxicity

Side effects

Nausea, vomiting, respiratory depression, and constipation are the most common side effects that occur with the use of piritramide. However, these occur less frequently than with the use of morphine and other opioids.

Sources

  • Drugbank
  • PubChem
  • Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
Markus Falkenstätter

Markus Falkenstätter
Author

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer
Lector

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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