Piritramide is a synthetic opioid analgesic marketed in certain European countries, including: Austria, Belgium, Czech Republic, Germany and the Netherlands. It is available in free form, is approximately 0.75 times more potent than morphine and is administered parenterally (by injection) for the treatment of severe pain.
Effect
Pharmacodynamics
Piritramide is a synthetic opioid and a µ-receptor agonist. Thus, the analgesic effect is due to binding to µ-receptors in the CNS.
Pharmacokinetics
After intravenous administration, the onset of analgesia is only 1-2 minutes, possibly related to its large lipophilicity. The volume of distribution is 0.7-1 L/kg after a single dose, 4.7-6 L/kg after steady-state concentrations are reached, and up to 11.1 L/kg after prolonged administration.
Contraindication
severe obstructive pulmonary disease (COPD)
concomitant use with MAO inhibitors
Respiratory depression
Coma
hypersensitivity
Toxicity
Side effects
Nausea, vomiting, respiratory depression, and constipation are the most common side effects that occur with the use of piritramide. However, these occur less frequently than with the use of morphine and other opioids.
Aktories, Förstermann, Hofmann, Starke: Allgemeine und spezielle Pharmakologie und Toxikologie, Elsvier, 2017
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Markus Falkenstätter, BSc Author
Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.
Mag. pharm. Stefanie Lehenauer Lector
Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.
The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.
