ATC Code D07AC18
Formula C27H36O8
Molar Mass (g·mol−1) 488,577
Physical State solid
CAS Number 73771-04-7
PUB Number 6714002
Drugbank ID DB01130
Solubility poorly soluble in water / highly soluble in ethanol


Prednicarbate belongs to the glucocorticoids and has anti-inflammatory and anti-allergic effects. It is used for external treatment of inflammatory skin diseases (e.g. atopic dermatitis) and to relieve itching.
Der Arzneistoff weist eine ähnliche Wirksamkeit wie Hydrocortison auf und zeichnet sich durch sein günstiges Nutzen-Risiko-Verhältnis aus, da die entzündungshemmende Wirkung kaum mit einer unerwünschten Hautatrophie (Ausdünnung der Haut) einhergeht.

Im Handel wird Prednicarbat in Form von Cremes, Salben und Lösungen vertrieben.



Like other glucocorticoids, prednicarbate binds to specific receptors after entering the cell, forming a complex. This enters the nucleus and subsequently causes altered gene expression and greater expression of proteins that inhibit the enzyme phospholipase A2. These proteins, known as lipocortins, can control inflammation in the human body by inhibiting the release of arachidonic acid (the precursor of pro-inflammatory prostaglandins and leukotrienes).


After topical application, prednicarbate is converted while still in the skin to the much more potent prednisolone-17-ethylcarbonate. This is degraded to prednisolone, metabolized in the liver and excreted renally.


Prednicarbate should not be administered in the presence of hypersensitivity to the active ingredient.

To avoid worsening of the clinical picture, prednicarbate should not be used in:

  • Vaccine reactions
  • Bacterial skin diseases
  • Rosacea
  • Perioral dermatitis
  • Acne
  • Skin ulcers

During pregnancy, large-area application of prednicarbate should be avoided, and during lactation, the active ingredient should not be applied to the breast area.


Side effects

Possible unwanted side effects include:

  • Irritation
  • Redness
  • Itching
  • Scaling
  • Cracking
  • Dry skin
  • Infections
Markus Falkenstätter

Markus Falkenstätter

Markus Falkenstätter ist Autor zu pharmazeutischen Themen in der Medizin-Redaktion von Medikamio. Er befindet sich im letzten Semester seines Pharmaziestudiums an der Universität Wien und liebt das wissenschaftliche Arbeiten im Bereich der Naturwissenschaften.

Mag. pharm Stefanie Lehenauer

Mag. pharm Stefanie Lehenauer

Stefanie Lehenauer ist seit 2020 freie Autorin bei Medikamio und studierte Pharmazie an der Universität Wien. Sie arbeitet als Apothekerin in Wien und ihre Leidenschaft sind pflanzliche Arzneimittel und deren Wirkung.

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