Pridinol

ATC CodeM03BX03, N04AA14
CAS number511-45-5
PUB number4904
Drugbank IDDB13642
Empirical formulaC20H25NO
Molar mass (g·mol−1)295,42
Physical statesolid
Melting point (°C)147–149

Basics

Pridinol is a centrally acting muscle relaxant. It is used to treat muscle spasms of a central or peripheral nature. It is mainly used for lumbalgia, torticollis and general muscle pain in adults. It is used perorally in the form of tablets or by intramuscular injection.

The drug was approved in Europe in 2018.

Pharmacology

Pharmacodynamics

The exact mechanism of action is not yet fully understood. However, pridinol is thought to have an atropine-like effect by blocking acetylcholine receptors in the brain, resulting in relaxation of skeletal muscle.

Pharmacokinetics

Complete absorption after oral administration occurs after about one hour. Pridinol is excreted partly unchanged, partly metabolized and eliminated by the kidney. The plasma half-life is between 14 and 18 hours.

Drug-Drug Interactions

When administered concomitantly with anticholinergics such as atropine, their effect may be considerably enhanced.

Toxicity

Adverse effects

  • Palpitations
  • Hypotension
  • Nausea
  • Gastrointestinal discomfort
  • Fatigue
  • Dizziness
  • Headache
  • Speech disorders
  • Restlessness

Contraindications

  • Hypersensitivity
  • Glaucoma
  • Prostatic hypertrophy
  • Urinary retention
  • Cardiac arrhythmias
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer



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