Prothipendyl is a weak acting tricyclic azaphenothiazine neuroleptic. It is used to treat agitation and agitation in patients with underlying psychiatric disorders. Indications for prothipendyl include dementia, depression, schizophrenia, anxiety, and psychosomatic disorders. It is also often used in the treatment of difficulty falling asleep because, unlike common benzodiazepines, it does not carry the potential for dependence.

Prothipendyl was first synthesized by Wilhelm Schuler.



Prothipendyl is a dopamine antagonist with high selectivity for D1 and D2 receptors. In addition, it has a low affinity for serotonin receptors of the 5-HT2A type. In higher doses, the drug has a sleep-inducing effect due to its sedative-hypnotic action. In addition to antipsychotic effects, prothipendyl also has antihistaminergic, antiemetic, and sedative properties.


The bioavailability of prothipendyl after oral administration is approximately 15%. Maximum plasma concentration is reached after approximately 1 h. The plasma half-life is around 2-3 hours. The substance is metabolized in the liver and excreted mainly in the urine.

Drug interactions

When taken concomitantly with drugs that have a depressant effect on the CNS, there may be a mutual enhancement of effect.

These include:

  • Benzodiazepines
  • Sedatives
  • Antihistamines
  • Alcohol
  • Antihypertensives

The effects of levodopa may be attenuated if taken concomitantly. Prothipendyl may counteract the vasoconstrictor effects of epinephrine and phenylephrine.


Side effects

Possible side effects are:

  • Lowered blood pressure
  • Circulatory weakness
  • Vertigo
  • Tachycardia

Less common side effects include weight gain, circulatory collapse, arrhythmias (including QT-time prolongation), leukopenia, epilepsy, dry mouth, photosensitivity, priapism, and amenorrhea.


  • Alcohol intoxication
  • Sedatives
  • Analgesics
  • Coma
  • Pregnancy and lactation

Chemical & physical properties

ATC Code N05AX07
Formula C16H19N3S
Molar Mass (g·mol−1) 285,41
Physical State solid
Melting Point (°C) <25 °C
Boiling Point (°C) 195–198
PKS Value 2,3
CAS Number 303-69-5
PUB Number 14670
Drugbank ID DB12958

Editorial principles

All information used for the content comes from verified sources (recognised institutions, experts, studies by renowned universities). We attach great importance to the qualification of the authors and the scientific background of the information. Thus, we ensure that our research is based on scientific findings.
Markus Falkenstätter, BSc

Markus Falkenstätter, BSc

Markus Falkenstätter is a writer on pharmaceutical topics in Medikamio's medical editorial team. He is in the last semester of his pharmacy studies at the University of Vienna and loves scientific work in the field of natural sciences.

Mag. pharm. Stefanie Lehenauer

Mag. pharm. Stefanie Lehenauer

Stefanie Lehenauer has been a freelance writer for Medikamio since 2020 and studied pharmacy at the University of Vienna. She works as a pharmacist in Vienna and her passion is herbal medicines and their effects.

The content of this page is an automated and high-quality translation from DeepL. You can find the original content in German here.


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