| ATC Code | N05AH04 |
| CAS number | 111974-69-7 |
| PUB number | 5002 |
| Drugbank ID | DB01224 |
| Empirical formula | C21H25N3O2S |
| Molar mass (g·mol−1) | 383,51 |
| Physical state | solid |
| Melting point (°C) | 172–173 |
| PKS value | 6,83 |
Quetiapine is an atypical antipsychotic medication (atypical neuroleptic) used to treat schizophrenia, bipolar disorder, and major depression. Quetiapine acts on both positive and negative symptoms of schizophrenia. It is taken by mouth and requires a prescription.
The mechanism of action of quetiapine is not yet fully understood. The antischizophrenic effect probably results from the interaction of the drug with dopamine type 2 (D2) and serotonin 2A (5HT2A) receptors. In bipolar depression and major depression, the effects of quetiapine could be attributed to the binding of this drug or its metabolite to the norepinephrine transporter. Additional effects of quetiapine, including somnolence, orthostatic hypotension, and anticholinergic effects, may result from antagonism of H1 receptors, adrenergic α1-receptors, and muscarinic M1-receptors, respectively.
The highest plasma concentration of quetiapine occurs 1.5 hours after oral administration. Plasma protein binding of quetiapine is 83%. The major active metabolite of quetiapine is norquetiapine (N-desalkylquetiapine). Quetiapine has an elimination half-life of 6 to 7 hours. Its metabolite, norquetiapine, has a half-life of 9 to 12 hours. Quetiapine is excreted after hepatic metabolism primarily via the kidneys (73%) and in the feces (20%), with the remainder (1%) excreted as the drug in its unmetabolized form.
Very common (>10% incidence) adverse effects
Common (1-10% incidence) adverse effects.
Rare (<1% incidence) adverse effects
Markus Falkenstätter, BSc
Mag. pharm. Stefanie Lehenauer
Browse our extensive database of medications from A-Z, including effects, side effects, and dosage.
All active ingredients with their effects, applications, and side effects, as well as the medications they are contained in.
Symptoms, causes, and treatments for common diseases and injuries.
The presented content does not replace the original package insert of the medication, especially regarding the dosage and effects of individual products. We cannot assume liability for the accuracy of the data, as the data has been partially converted automatically. Always consult a doctor for diagnoses and other health-related questions.
© medikamio